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  • Biotin

    D-Biotin Struktur
    58-85-5
    CAS-Nr.
    58-85-5
    Bezeichnung:
    Biotin
    Englisch Name:
    D-Biotin
    Synonyma:
    BIOTIN;VITAMIN B7;VITAMIN H;5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]iMidazol-4-yl)pentanoic acid;BIOEPIDERM;5-(2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid;BIOS H;BIOTINUM;BIOTIN(V-H);ETHYLPHENYLETHANOL
    CBNumber:
    CB3271542
    Summenformel:
    C10H16N2O3S
    Molgewicht:
    244.31
    MOL-Datei:
    58-85-5.mol

    Biotin Eigenschaften

    Schmelzpunkt:
    231-233 °C(lit.)
    Siedepunkt:
    573.6±35.0 °C(Predicted)
    alpha 
    89 º (c=1, 0.1N NaOH)
    Dichte
    1.2693 (rough estimate)
    chüttdichte
    200-500kg/m3
    Brechungsindex
    90.5 ° (C=2, 0.1mol/L NaOH)
    storage temp. 
    -20°C
    L?slichkeit
    H2O: 0.2 mg/mL Solubility increases with addition of 1 N NaOH.
    Aggregatzustand
    powder
    pka
    4.74±0.10(Predicted)
    Farbe
    White crystalline powder or fine long needles
    PH
    4.5 (0.1g/l, H2O)
    Optische Aktivit?t
    [α]20/D +91±2°, c = 1% in 0.1 M NaOH
    Biologische Quelle
    synthetic (organic)
    Wasserl?slichkeit
    Soluble in hot water, dimethyl sulfoxide, alcohol and benzene.
    Sensitive 
    Light Sensitive
    Merck 
    14,1231
    BRN 
    86838
    Stabilit?t:
    Stable, but light sensitive. Incompatible with strong oxidizing agents, strong bases, strong acids, formaldehyde, chloramine-T, nitrous acid.
    InChIKey
    YBJHBAHKTGYVGT-ZKWXMUAHSA-N
    LogP
    0.861 (est)
    CAS Datenbank
    58-85-5(CAS DataBase Reference)
    NIST chemische Informationen
    Biotin(58-85-5)
    EPA chemische Informationen
    Biotin (58-85-5)
    Sicherheit
    • Risiko- und Sicherheitserkl?rung
    • Gefahreninformationscode (GHS)
    Kennzeichnung gef?hrlicher Xn
    R-S?tze: 20/21/22-36/37/38
    S-S?tze: 24/25-36-26
    WGK Germany  1
    RTECS-Nr. XJ9088200
    8
    TSCA  Yes
    HS Code  29362930
    Giftige Stoffe Daten 58-85-5(Hazardous Substances Data)
    Toxizit?t LD50 orally in Rabbit: > 2000 mg/kg
    Bildanzeige (GHS) GHS hazard pictograms
    Alarmwort Warnung
    Gefahrenhinweise
    Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
    H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
    H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
    H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
    Sicherheit
    P261 Einatmen von Staub vermeiden.
    P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
    P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

    Biotin Chemische Eigenschaften,Einsatz,Produktion Methoden

    R-S?tze Betriebsanweisung:

    R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

    S-S?tze Betriebsanweisung:

    S24/25:Berührung mit den Augen und der Haut vermeiden.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

    Chemische Eigenschaften

    White powder

    Verwenden

    Growth factor present in minute amounts in every living cell. Plays an indispensable role in numerous naturally occurring carboxylation reactions. Occurs mainly bound to proteins or polypeptides. The richest sources are liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tumors is higher than that of normal tissue.

    Definition

    ChEBI: An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins.

    Allgemeine Beschreibung

    Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
    Biotin is a water-soluble vitamin, essential for amino acids and carbohydrates metabolism. It is involved in de novo synthesis of purine nucleotides and plays a role in gene expression and DNA replication.

    Sicherheitsprofil

    An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.

    l?uterung methode

    D-(+)-Biotin crystallises from hot water in fine long needles with a solubility of 22 mg/100mL at 25o. Its solubility in 95% EtOH is 80 mg/100 mL at 25o. Its isoelectric point is at pH 3.5. Store solid and solutions under sterile conditions because it is susceptible to mould growth. [Confalone J Am Chem Soc 97 5936 1975, Wolf et al. J Am Chem Soc 67 2100 1945, Synthesis: Ohuri & Emoto Tetrahedron Lett 2765 1975, Harris et al. J Am Chem Soc 66 1756 1944.] The (+)-methyl ester has m 166-167o (from MeOH/Et2O), [] D 22 +57o (c 1, CHCl3) [du Vigneaud et al. J Biol Chem 140 643, 763 1941]; the (+)-S-oxide has m 200-203o, [] D 20 +130o (c 1.2, 0.1N NaOH) [Melville J Biol Chem 208 495 1954]; the SS-dioxide has m 274-275o(dec, 268-270o), and the SS-dioxide methyl ester has m 239-241o (from MeOH/Et2O) [Hofmann et al. J Biol Chem 141 207, 213 1941]. [Beilstein 27 III/IV 7979.]

    Biotin Upstream-Materialien And Downstream Produkte

    Upstream-Materialien

    Downstream Produkte


    Biotin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

    Global( 1144)Lieferanten
    Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
    LEAP CHEM CO., LTD.
    +86-852-30606658
    market18@leapchem.com China 24727 58
    Xi'an Kono chem co., Ltd.,
    029-86107037 13289246953
    info@konochemical.com China 1169 58
    Dayang Chem (Hangzhou) Co.,Ltd.
    571-88938639 +8617705817739
    info@dycnchem.com China 52849 58
    Guangzhou TongYi biochemistry technology Co.,LTD
    +8613073028829
    mack@tongyon.com China 2994 58
    XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
    +86-029-86333380 18829239519
    sales06@tgybio.com China 900 58
    TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD
    +86-576-88902229;+86-0576-88902229 +8613968687450
    yuxin@yuxchem.com China 167 58
    Aladdin Scientific
    +1-+1(833)-552-7181
    sales@aladdinsci.com United States 57505 58
    Wuhan Fortuna Chemical Co., Ltd
    +86-027-59207850
    info@fortunachem.com China 5973 58
    Hebei Weibang Biotechnology Co., Ltd
    +8615531157085
    abby@weibangbio.com China 8806 58
    Shaanxi Dideu Medichem Co. Ltd
    +86-29-81148696 +86-15536356810
    1022@dideu.com China 3882 58

    58-85-5(Biotin)Verwandte Suche:


    • PHOTOPROBE(R) BIOTIN
    • D-(+)-Biotin,98+%
    • D-BIOTIN, 1%, 2% (VITAMIN H)
    • (+)-Biotin , Vitamin B7, Coenzyme R
    • 1H-Thieno3,4-dimidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)-
    • BIOTIN,POWDER,FCC
    • BIOTIN,POWDER,USP
    • 5-(7-oxo-3-thia-6,8-diazabicyclo[3.3.0]oct-4-yl)pentanoic acid
    • 1% BIOTIN
    • 2% BIOTIN(FEEDSTUFFS GRADE)
    • 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, [3aS-(3aα,4β,6aα)]-
    • cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid
    • Lutavit H2
    • Meribin
    • Rovimix H 2
    • (+)-BIOTIN
    • FACTOR S
    • HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID
    • COENZYME R
    • D-(+)-Biotin Food Grade, 1% on DCP
    • D-Biotin 1%
    • D-Biotin Food Grade, 2%, Powder
    • D-BIOTIN (VITAMIN H)
    • D-BiotinForBiochemistry
    • D-BiotinCrystalline,>99%
    • Biotine-D
    • D-BiotinCrystalline
    • BiphenylForSynthesis
    • D-Biotin,Pure,2%,1%
    • D-Biotin(Biotin,VitaminH)
    • VitaminHforanimalnutrition
    • 4S,7S,8R-Hexahydro-2-oxothieno[3,4-d]imidazol-4-pentansure
    • HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID, VITAMIN H
    • BIOTIN 1% FEED GRADE
    • (3AS,4S,6AR)-HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID
    • D-BIOTIN USP
    • D(+)-Biotin >99.5%
    • D-BIOTIN FCC (VITAMIN H)
    • D-BIOTIN USP (VITAMIN H)
    • D(+)-Biotin, 98% 5GR
    • 5-(2-Hydroxy-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]iMidazol-6-yl)-pentanoic acid
    • 3,3'-DiaMethyl-4,4'-diaMinodicyclohexylMethane(MACM)
    • D(+)-Biotin 0
    • Biotin (Vitamin B7)
    • Biotin Vetec(TM) reagent grade, >=99%
    • 15720-24-8
    • 1H-Thieno(3,4-d)imidazole-4-pen
    • 3672-05-7
    • BSPBio_002329
    • DivK1c_000311
    • IDI1_000311
    • KBio2_000705
    • Biotine pure
    • CIS-HEXAHYDRO-2-OXO-1H-THIENE[3,4]IMIDAZOLE-4-VALERIC ACID
    • D-CIS-HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID
    • D(+)-BIOTIN
    • D-BIOTIN
    • 5-((3AR,6S,6AS)-2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC ACID
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