????
|
|
???? ??
- ???
- 231-233 °C(lit.)
- ?? ?
- 573.6±35.0 °C(Predicted)
- ??
- 89 º (c=1, 0.1N NaOH)
- ??
- 1.2693 (rough estimate)
- ???
- 90.5 ° (C=2, 0.1mol/L NaOH)
- ?? ??
- -20°C
- ???
- H2O: 0.2 mg/mL 1 N NaOH? ???? ???? ?????.
- ??? ??
- ??
- ?? ?? (pKa)
- 4.74±0.10(Predicted)
- ??
- ??? ??? ?? ?? ?? ? ??
- ??????(pH)
- 4.5 (0.1g/l, H2O)
- optical activity
- [α]20/D +91±2°, c = 1% in 0.1 M NaOH
- ???
- ??? ?, ????????, ???, ??? ?????.
- ??
- Light Sensitive
- Merck
- 14,1231
- BRN
- 86838
- ???
- ?????? ?? ?????. ????, ???, ??, ??????, ????-T, ???? ???? ????.
- InChIKey
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N
- LogP
- 0.861 (est)
- CAS ??????
- 58-85-5(CAS DataBase Reference)
- NIST
- Biotin(58-85-5)
- EPA
- Biotin (58-85-5)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 20/21/22-36/37/38 | ||
| ????? | 24/25-36-26 | ||
| WGK ?? | 1 | ||
| RTECS ?? | XJ9088200 | ||
| F ?????? | 8 | ||
| TSCA | Yes | ||
| HS ?? | 29362930 | ||
| ?? ?? ??? | 58-85-5(Hazardous Substances Data) | ||
| ?? | LD50 orally in Rabbit: > 2000 mg/kg | ||
| ???? ?? | KE-18590 |
???? C??? ??, ??, ??
????
? (1) ?? : ? ??? ?????? ?? ??? ?, ? ?? 2.6ppm ????? ??.
??(2) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 2.0ppm ????? ??.
??(3) ?? : ? ??? ??? 229～232℃??? ??.
??(4) ???? : ? ?? ? 500mg? ??? ?? 0.1N ????????? ?? 25mL? ?? ???? ??? ?, 
＝+89～+93°??? ??.
??(5) ???? : ? ?? 0.1g? ??? ?? ?????(7→100)? ??? ??? ??? 10mL? ? ?? ?????? ??. ???? 1mL? ??? ?????(7→100)? ??? ??? 500mL? ? ?? ?????? ??. ???? ? ??? 5μL? ??? n-????????? ??(5 : 2 : 1)? ??????? ?????????? ??? ????? ??? ?????? ? 10cm ????? ? ??? ????, ??? ??, ?? 105℃?? 30?? ??? ?, p-??????????????????(1→500)/????????(1→50)? ???? ??? ?, ??? ????? ????? ?? ?? ???? ??? ??????? ?? ??? ???? ?? ??. ??, ???? ??? ?????????? ????? 110℃?? 1?? ???? ?? ????.
????
? ? ??? ??? ?? ????? ??? 1??? ????? ????? ????.
???
? ? ?? ? 500mg? ??? ?? ? 100mL? ?? ???? ????????? ?? ? ???? ???? ?? ??? ??? 0.1N ?????????? ??? ? ??? ??? ????.
0.1N ???????? 1mL ＝ 24.43mg C10H16N2O3S
??? ??
White powder??
Growth factor present in minute amounts in every living cell. Plays an indispensable role in numerous naturally occurring carboxylation reactions. Occurs mainly bound to proteins or polypeptides. The richest sources are liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tumors is higher than that of normal tissue.??
ChEBI: An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins.?? ??
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Biotin is a water-soluble vitamin, essential for amino acids and carbohydrates metabolism. It is involved in de novo synthesis of purine nucleotides and plays a role in gene expression and DNA replication.
Safety Profile
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.Purification Methods
D-(+)-Biotin crystallises from hot water in fine long needles with a solubility of 22 mg/100mL at 25o. Its solubility in 95% EtOH is 80 mg/100 mL at 25o. Its isoelectric point is at pH 3.5. Store solid and solutions under sterile conditions because it is susceptible to mould growth. [Confalone J Am Chem Soc 97 5936 1975, Wolf et al. J Am Chem Soc 67 2100 1945, Synthesis: Ohuri & Emoto Tetrahedron Lett 2765 1975, Harris et al. J Am Chem Soc 66 1756 1944.] The (+)-methyl ester has m 166-167o (from MeOH/Et2O), [] D 22 +57o (c 1, CHCl3) [du Vigneaud et al. J Biol Chem 140 643, 763 1941]; the (+)-S-oxide has m 200-203o, [] D 20 +130o (c 1.2, 0.1N NaOH) [Melville J Biol Chem 208 495 1954]; the SS-dioxide has m 274-275o(dec, 268-270o), and the SS-dioxide methyl ester has m 239-241o (from MeOH/Et2O) [Hofmann et al. J Biol Chem 141 207, 213 1941]. [Beilstein 27 III/IV 7979.]???? ?? ?? ? ???
???
?? ??
???? ?? ??
???( 1138)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24727 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 1169 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52849 | 58 |
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 |
mack@tongyon.com | China | 2994 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 901 | 58 |
| TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD | +86-576-88902229;+86-0576-88902229 +8613968687450 |
yuxin@yuxchem.com | China | 167 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57505 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5975 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 |
abby@weibangbio.com | China | 8810 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3882 | 58 |