成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Dacomitinib (PF299804)

Dacomitinib (PF299804) Struktur
1110813-31-4
CAS-Nr.
1110813-31-4
Englisch Name:
Dacomitinib (PF299804)
Synonyma:
Dacomitinib;PF299804;(E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enaMide;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide Dacomitinib (PF299804, PF299);PF299;CS-168;Dachtini;Dakotinib;dacatinib;Dacotinib
CBNumber:
CB22566418
Summenformel:
C24H25ClFN5O2
Molgewicht:
469.94
MOL-Datei:
1110813-31-4.mol

Dacomitinib (PF299804) Eigenschaften

Schmelzpunkt:
184-187°C
Siedepunkt:
665.7±55.0 °C(Predicted)
Dichte
1.344
storage temp. 
Refrigerator
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Heated)
Aggregatzustand
White solid.
pka
12.05±0.43(Predicted)
Farbe
White to Pale Yellow
InChIKey
LVXJQMNHJWSHET-AATRIKPKSA-N
SMILES
C(NC1C(OC)=CC2C(C=1)=C(NC1=CC=C(F)C(Cl)=C1)N=CN=2)(=O)/C=C/CN1CCCCC1
CAS Datenbank
1110813-31-4
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  29335990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Dacomitinib (PF299804) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The epidermal growth factor receptors (EGFR), whose members include ErbB1 (HER1), ErbB2 (HER2), ErbB3 (HER3), and ErbB4 (HER4), are receptor tyrosine kinases that are often over-expressed in cancer. PF-299804 is a second generation pan-ErbB receptor tyrosine kinase inhibitor (IC50s = 6, 45.7, and 73.7 nM for ErbB1, ErbB2, and ErbB4, respectively) that irreversibly binds to the ATP site in the catalytic domains of ErbB receptors. At 15 mg/kg, it demonstrates antitumor activity ranging from delay in tumor growth to complete regression in various tumor xenograft models expressing either wild-type ErbB or mutant ErbB family members that show resistance to first generation ErbB kinase inhibitors.

Verwenden

PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

Definition

ChEBI: A member of the class of quinazolines that is 7-methoxyquinazoline-4,6-diamine in which the amino group at position 4 is substituted by a 3-chloro-4-fluorophenyl group and the amino group at position 6 is substituted by an (E)-4-(piperidin 1-yl)but-2-enoyl group.

Trademarks

VizimproTM

Dacomitinib (PF299804) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Dacomitinib (PF299804) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 353)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Protheragen-ING
+16313385890
 info@protheragen-ing.com United States 3868 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177
 peter@yan-xi.com China 5857 58
shandong perfect biotechnology co.ltd 		+86-53169958659 +86-13153181156
 sales@sdperfect.com China 294 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 10986 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858
 daisy@anhuiruihan.com China 973 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649
 sarah@tnjone.com China 1143 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
Shanghai Bojing Chemical Co.,Ltd. 		+86-86-02137122233 +8613795318958
 bj1@bj-chem.com China 299 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714
 FandaChem@Gmail.com China 9087 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55

1110813-31-4()Verwandte Suche:

  • PF-00299804-03
  • PF-00299804
  • DacoMitinib (PF-00299804)
  • DacoMitinib,PF299804
  • DacoMitinib (PF299804,PF-00299804)
  • PF299804;DACOMITINIB
  • DacoMitinib (PF299804, PF299)
  • (E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquizolin-6-yl)-4-(piperidin-1-yl)but-2-eMide
  • dacomitinib (pan-HER inhibitor)
  • (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
  • Dacomitinib, >=98%
  • 2-Butenamide,N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-, (2E)-
  • PF299
  • PF299804;(E)-N-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-METHOXYQUINAZOLIN-6-YL)-4-(PIPERIDIN-1-YL)BUT-2-ENAMIDE
  • (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
  • PF299804 (Dacomitinib, PF299)
  • PF299804, PF299)
  • PF-299804 (Dacomitinib,PF-00299804)
  • CS-168
  • PF299804; DACOMITINIB; PF-00299804;PF-299804;PF 299804
  • Dacomitinib, 98%, a potent irreversible ErbB inbibitor
  • Dacomitinib (USAN/INN)
  • Dacomitinib [USAN]
  • Dacomitinib Dacomitinib
  • Dacomitinib-D10
  • Dacomitinib (PF299804) USP/EP/BP
  • Dacomitinib dihydrochloride salt
  • Dacomitinib D10 dihydrochlorideQ: What is Dacomitinib D10 dihydrochloride Q: What is the CAS Number of Dacomitinib D10 dihydrochloride
  • Dacomitinib D3
  • Dacomitinib D5
  • Dacomitinib
  • (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide Dacomitinib (PF299804, PF299)
  • PF299804
  • (E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enaMide
  • Dachtini
  • Dacomitinib free base
  • Dacomitinib / PF 00299804-03
  • Dakotinib
  • dacatinib
  • Dacotinib
  • 1110813-31-4
  • C24H25ClFN5O2
  • Inhibitors
  • Anti-cancer&immunity
  • API
  • API
  • 1
  • APIs
Copyright 2019 ? ChemicalBook. All rights reserved