Dexrazoxane
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- CAS-Nr.
- 24584-09-6
- Englisch Name:
- Dexrazoxane
- Synonyma:
- adr529;cardioxane;DEXRAZOXANE;DEXTRAZOXANE;(S)-ICRF-187;DEXTRORAZOXANE;Dexrazoxane>Right razoxane;(+)-dexrazoxane;Dexrazoxane, >=99%
- CBNumber:
- CB2251448
- Summenformel:
- C11H16N4O4
- Molgewicht:
- 268.27
- MOL-Datei:
- 24584-09-6.mol
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Dexrazoxane Eigenschaften
- Schmelzpunkt:
- 194-196°C
- alpha
- D +11.35° (c = 5 in DMF)
- Siedepunkt:
- 531.5±50.0 °C(Predicted)
- Dichte
- 1.333±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >20mg/mL
- Aggregatzustand
- powder
- pka
- 2.1(at 25℃)
- Farbe
- white to off-white
- Merck
- 14,8123
- InChIKey
- BMKDZUISNHGIBY-ZETCQYMHSA-N
- CAS Datenbank
- 24584-09-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Dexrazoxane Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the
cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the
anticancer effect of doxorubicin. Its mode of action suggests a chelation of free
radicals. In mice, dexrazoxane also offers protection against cardiac side effects of
epirubicin, but not mitoxantrone.
Verwenden
Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.
Allgemeine Beschreibung
Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.
Biologische Aktivit?t
Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.
Dexrazoxane Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dexrazoxane Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 300)Lieferanten
24584-09-6()Verwandte Suche:
- DEXRAZOXANE
- (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione
- 4’-(1-methyl-1,2-ethanediyl)bis-6-piperazinedion(+)-4
- 4’-propylenedi-6-piperazinedion(+)-4
- adr529
- cardioxane
- DEXTRAZOXANE
- DEXTRORAZOXANE
- (S)-ICRF-187
- [S,(+)]-4,4'-Propylenebis(2,6-piperazinedione)
- 4,4'-[(S)-1-Methyl-1,2-ethanediyl]bis(2,6-piperazinedione)
- 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dionehydrochloride
- 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
- (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
- Dexrazoxane ((S)-Razoxane)
- 2,6-Piperazinedione,4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-
- (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione
- (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
- Dexrazoxane (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione)
- Dexrazoxane, >=99%
- (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane
- Ca rdioxane、Dextrazoxane、Eucardion、Zinecard
- ICRF-187;NSC-169780
- Dexrazoxane
(ICRF-187
- Dexrazoxane>
- (+)-dexrazoxane
- Dexrazoxane Impurity
- Dexrazoxane (NSC-169780)
- Right razoxane
- Dextrozosan. - Dextropropimide
- Dexrazoxane 24584-09-6
- 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione
- 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-
- 24584-09-6
- C11H16N4O4
- API
- Chelating Agent
- 24584-09-6
