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Norfloxacin

Norfloxacin Struktur
70458-96-7
CAS-Nr.
70458-96-7
Bezeichnung:
Norfloxacin
Englisch Name:
Norfloxacin
Synonyma:
NORFLOXACINE;NORFLOXACIN LACTATE;noroxin;Floxacin;chibroxin;1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylica;4803P;Noflo;NorfL;Utinor
CBNumber:
CB1711035
Summenformel:
C16H18FN3O3
Molgewicht:
319.33
MOL-Datei:
70458-96-7.mol

Norfloxacin Eigenschaften

Schmelzpunkt:
220°C
Siedepunkt:
555.8±50.0 °C(Predicted)
Dichte
1.2504 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
L?slichkeit
Very slightly soluble in water, slightly soluble in acetone and in ethanol (96 per cent).
Aggregatzustand
Crystalline Powder
pka
pKa1 6.34; pKa2 8.75(at 25℃)
Farbe
White to yellow
Wasserl?slichkeit
Soluble in acetic acid. Also soluble in acetone or cloroform. Slightly soluble in water
Merck 
14,6700
Stabilit?t:
Hygroscopic
InChI
InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
InChIKey
OGJPXUAPXNRGGI-UHFFFAOYSA-N
SMILES
N1(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C(=O)C(C(O)=O)=C1
CAS Datenbank
70458-96-7(CAS DataBase Reference)
EPA chemische Informationen
3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)- (70458-96-7)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22-36/37/38
S-S?tze: 26-37/39-24/25
WGK Germany  2
RTECS-Nr. VB2005000
HazardClass  IRRITANT
HS Code  29335990
Giftige Stoffe Daten 70458-96-7(Hazardous Substances Data)
Toxizit?t LD50 in mice, rats (mg/kg): >4000 orally (both species); 1500 s.c. (both species); 470, >500 i.m.; 220, 270 i.v. (Irikura)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Norfloxacin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Norfloxacin is the first of the third generation nalidixic acid analogs to reach the marketplace. It exhibits potent in vitro and in vivo activity against Pseudomonas, enteric gram-negative rods and gram-positive cocci. Norfloxacin is orally effective in the treatment of urinary tract infections, including those due to organisms refractory to many other agents.

Chemische Eigenschaften

Off-white to light yellow cryst powder

Verwenden

It finds it application as a fluorinated quinolone antibacterial. It is clinically used to treat urinary tract infections and prostatitis. In neutrophils from cirrhotic subjects, norfloxacin increases expression of IL-10 and heme oxygenase 1 (HO-1) and decreases expression of pro-inflammatory cytokines. Additionally, when complexed with gold(III), norfloxacin binds DNA and inhibits cellular proliferation in several cancer cell lines.

Definition

ChEBI: A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enz me called DNA gyrase.

Antimicrobial activity

It is active against a wide range of Gram-negative bacteria, including Enterobacteriaceae and Campylobacter spp. Ps. aeruginosa, Acinetobacter, Serratia and Providencia spp. are weakly susceptible (and often resistant). It has no useful activity against anaerobes, Chlamydia, Mycoplasma and Mycobacterium spp.

Pharmazeutische Anwendungen

A 6-fluoro, 7-piperazinyl quinoline available for oral administration and as an ophthalmic ointment.

Pharmakokinetik

Oral absorption: 50–70%
Cmax 400 mg oral :1.5 mg/L after 1–1.5 h
Plasma half-life :3–4 h
Volume of distribution: 2.5–3.1 L/kg
Plasma protein binding: 15%
absorption and distribution
Norfloxacin displays linear kinetics. There is no significant accumulation with the recommended dosage of 400 mg every 12 h. Food slightly delays but does not otherwise impair absorption. Antacids reduce absorption. It is widely distributed, but concentrations in tissues other than those of the urinary tract are low: levels in the prostate are around 2.5 mg/g.
Metabolism and excretion
Six or more inactive metabolites are produced. Around 30% of a dose appears as unchanged drug in the urine and <10% as metabolites, producing peak concentrations of microbiologically active drug of around 100–400 mg/L. Urinary recovery is halved by probenecid, with little effect on the plasma concentration. The apparent plasma elimination half-life increases with renal impairment, rising to around 8 h in the anuric patient. Some of the drug appears in the bile where concentrations three- to seven-fold greater than the simultaneous plasma levels are achieved, but this is not a significant route of elimination and hepatic impairment is without effect. Very variable quantities, averaging 30% of a dose, appear in the feces, producing concentrations of active agent of around 200–2000 mg/kg.

Clinical Use

Complicated and uncomplicated urinary tract infections (including prophylaxis in recurrent infections), prostatitis
Uncomplicated gonorrhea
Gastroenteritis caused by Salmonella, Shigella and Campylobacter spp., Vibrio cholerae
Conjunctivitis (ophthalmic preparation)

Nebenwirkungen

Untoward reactions are those common to the fluoroquinolones. Gastrointestinal tract disturbances, which are generally mild, have been reported in 2–4% of patients. CNS disturbances have largely been limited to headache, drowsiness and dizziness. Co-administration with theophylline results in increased plasma theophylline levels.

Sicherheitsprofil

Poison by intravenous route.Moderately toxic by other routes. Human systemic effectsby ingestion: musculoskeletal changes. An experimentalteratogen. Other experimental reproductive effects.Mutation data reported. When heated to decomposition itemits

Norfloxacin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Norfloxacin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 763)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zibo Wei Bin Import & Export Trade Co. Ltd.
+86-0533-2091136 +8613864437655
ziboweibinmaoyi@163.com China 100 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
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+8618092446649
sarah@tnjone.com China 1143 58
Henan Suikang Pharmaceutical Co.,Ltd.
+86-18239973690 +86-18239973690
sales@suikangpharm.com China 311 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2691 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58

70458-96-7(Norfloxacin)Verwandte Suche:


  • Zoroxin
  • NORFLOXACINUM
  • Norfloxacin (base and/or unspecified salts)
  • 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • 4803P
  • MK-0366
  • Norfloxacin(Nicotinate&Hcl)
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • 1-Ethvl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • Chibroxol
  • Fulgram
  • Gonorcin
  • Lexinor
  • Noflo
  • Nolicin
  • Noracin
  • Noraxin
  • Noroein
  • Noroxin(e)
  • Norxaein
  • Uroxacin
  • Utinor
  • Zomxin
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid
  • Norfloxacin (200 mg)
  • Noroxacin (200 mg)
  • 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid
  • Norfloxacin Lactate Injectio
  • AKOS NCG-0042
  • NORFLOXACIN USP 22
  • NorfloxacinUsp2699%Min
  • Barazan
  • N-Demethylpefloxacin
  • Norxacin
  • Sebercim
  • Norfloxacin(Norxacin)
  • Norfloxacin COS
  • Norfloxacin, 98%, analytical standard
  • Norfloxacin Standards
  • 1-ethyl-6-fluoro-4-keto-7-piperazin-1-yl-quinoline-3-carboxylic acid
  • 1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylic acid
  • 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
  • BCBcMAP01_000218
  • BSPBio_002107
  • D00210
  • KBio2_004065
  • MLS000069650
  • NINDS_000084
  • Norflo
  • Norfloxacin (JP15/USP/INN)
  • Noroxin (TN
  • Prestwick1_000221
  • Prestwick3_000221
  • SMR000058200
  • SPBio_002182
  • Norfloxacin for peak identification
  • ORFLOXACIN
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