Edrophonium chloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White or almost white, crystalline powder
Verwenden
Pharmacologically, edrophonium is also similar to neostigmine; however, it begins to act
quicker and is shorter lasting.
Verwenden
A reversible Acetylcholinesterase inhibitor.
Definition
ChEBI: The chloride salt of edrophonium. A reversible inhibitor of cholinesterase with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes), it is used in myasthenia gravis both diagnostically and to distinguish between unde
- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other mari
e animals.
Allgemeine Beschreibung
Edrophonium chloride,ethyl(m-hydroxyphenyl)dimethylammonium chloride(Tensilon), is a reversible anticholinesterase agent. It isbitter and very soluble in water and alcohol. Edrophoniumchloride injection has a pH of 5.2 to 5.5. On parenteral administration,edrophonium has a more rapid onset andshorter duration of action than neostigmine, pyridostigmine,or ambenonium. It is a specific anticurare agent andacts within 1 minute to alleviate overdose of d-tubocurarine,dimethyl d-tubocurarine, or gallamine triethiodide.
Clinical Use
Edrophonium Chloride is also used to terminate the action of any one ofthese drugs when the physician so desires. It is of no value,however, in terminating the action of the depolarizing (i.e.,noncompetitive) blocking agents, such as decamethoniumand succinylcholine. In addition to inhibiting AChE, edrophoniumchloride has a direct cholinomimetic effect onskeletal muscle, which is greater than that of most otheranticholinesterase drugs.
Synthese
Edrophonium, ethyl-(3-hydroxyphenyl)dimethylammonium chloride
(13.2.13), is made by reacting 3-dimethylaminophenol with ethylbromide, which forms
ethyl(3-hydroxyphenyl)dimethylammonium bromide (13.2.12), the bromine atom of
which is replaced with a chlorine atom by reacting it with silver chloride, giving edrophonium (13.2.13) [45].
Edrophonium chloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte