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Edrophonium chloride

Edrophonium chloride Struktur
116-38-1
CAS-Nr.
116-38-1
Englisch Name:
Edrophonium chloride
Synonyma:
Enlon;antirex;tensilon;Reversol;Edrophonium;Tensilon Chloride;EDROPHONIUM CHLORIDE;Edrophonium Chloride RS;Edrophonium chloride CRS;Edrophonium Chloride (200 mg)
CBNumber:
CB1170926
Summenformel:
C10H16ClNO
Molgewicht:
201.69
MOL-Datei:
116-38-1.mol

Edrophonium chloride Eigenschaften

Schmelzpunkt:
162-163 °C (decomp)
Dichte
1.0787 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
Very soluble in water, freely soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
Aggregatzustand
A crystalline solid
Farbe
White to light yellow
InChIKey
BXKDSDJJOVIHMX-UHFFFAOYSA-N
CAS Datenbank
116-38-1(CAS DataBase Reference)

Sicherheit

WGK Germany  3
RTECS-Nr. BQ5870000
HS Code  2923900100
Toxizit?t mouse,LD50,intraperitoneal,30mg/kg (30mg/kg),Pharmaceutical Chemistry Journal Vol. 10, Pg. 327, 1976.

Edrophonium chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White or almost white, crystalline powder

Verwenden

Pharmacologically, edrophonium is also similar to neostigmine; however, it begins to act quicker and is shorter lasting.

Verwenden

A reversible Acetylcholinesterase inhibitor.

Definition

ChEBI: The chloride salt of edrophonium. A reversible inhibitor of cholinesterase with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes), it is used in myasthenia gravis both diagnostically and to distinguish between unde - or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other mari e animals.

Allgemeine Beschreibung

Edrophonium chloride,ethyl(m-hydroxyphenyl)dimethylammonium chloride(Tensilon), is a reversible anticholinesterase agent. It isbitter and very soluble in water and alcohol. Edrophoniumchloride injection has a pH of 5.2 to 5.5. On parenteral administration,edrophonium has a more rapid onset andshorter duration of action than neostigmine, pyridostigmine,or ambenonium. It is a specific anticurare agent andacts within 1 minute to alleviate overdose of d-tubocurarine,dimethyl d-tubocurarine, or gallamine triethiodide.

Clinical Use

Edrophonium Chloride is also used to terminate the action of any one ofthese drugs when the physician so desires. It is of no value,however, in terminating the action of the depolarizing (i.e.,noncompetitive) blocking agents, such as decamethoniumand succinylcholine. In addition to inhibiting AChE, edrophoniumchloride has a direct cholinomimetic effect onskeletal muscle, which is greater than that of most otheranticholinesterase drugs.

Synthese

Edrophonium, ethyl-(3-hydroxyphenyl)dimethylammonium chloride (13.2.13), is made by reacting 3-dimethylaminophenol with ethylbromide, which forms ethyl(3-hydroxyphenyl)dimethylammonium bromide (13.2.12), the bromine atom of which is replaced with a chlorine atom by reacting it with silver chloride, giving edrophonium (13.2.13) [45].

Synthesis_116-38-1

Edrophonium chloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Edrophonium chloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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116-38-1()Verwandte Suche:


  • ETHYL[M-HYDROXYPHENYL]-DIMETHYLAMMONIUM CHLORIDE
  • EDROPHONIUM CHLORIDE
  • N-Ethyl-3-hydroxy-N,N-diMethyl-benzenaMiniuM Chloride
  • Reversol
  • Tensilon Chloride
  • antirex
  • dimethylethyl(m-hydroxyphenyl)-ammoniuchloride
  • ethyl(m-hydroxyphenyl)dimethyl-ammoniuchloride
  • n-ethyl-3-hydroxy-n,n-dimethyl-benzenaminiuchloride
  • tensilon
  • ethyl(3-hydroxyphenyl)dimethylammonium chloride
  • N-ethyl-3-hydroxy-N,N-dimethylanilinium chloride
  • Edrophonium
  • Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride
  • Enlon
  • Dimethylethyl(m-hydroxyphenyl)ammonium chloride
  • Edrophonium Chloride (200 mg)
  • Edrophonium Chloride (1234001)
  • Edrophonium chloride USP/EP/BP
  • Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride (1:1)
  • Edrophonium chloride CRS
  • Edrophonium Chloride RS
  • 116-38-1
  • C10H16NOCl
  • C10H11NOD5Cl
  • Acetycholinesterase inhibitor
  • A to C
  • Biochemicals and Reagents
  • BioChemical
  • Cholinesterase, acetyl
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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