896705-16-1
中文名稱(chēng)
BMH-21
英文名稱(chēng)
BMH21
CAS
896705-16-1
分子式
C21H20N4O2
更新日期
2025/03/13 08:55:07
分子量
360.41
MOL 文件
896705-16-1.mol
896705-16-1 結(jié)構(gòu)式
基本信息
中文別名
RNA POLYMERASE I轉(zhuǎn)錄抑制劑(BMH-21)N-(2-(二甲氨基)乙基)-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺
N-[2-(二甲基氨基)乙基]-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺
英文別名
BMH21CS-1749
BMH-21, >98%
BMH 21
BMH21
BMH21 USP/EP/BP
N-[2-(Dimethylamino)ethyl]-12-oxo-5,13-diazatetracene-4-carboxamide
N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-
BMH-21 N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
所屬類(lèi)別
生物化工：DNA/RNA Synthesis 抑制劑物理化學(xué)性質(zhì)
密度1.28±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO：可溶1mg/mL，澄清（加熱）
酸度系數(shù)(pKa)7.90±0.20(Predicted)
形態(tài)粉末
顏色淡黃色至深黃色
常見(jiàn)問(wèn)題列表
生物活性
BMH-21是一種DNA嵌入劑，與核糖體DNA結(jié)合，并抑制RNA polymerase I (Pol I)轉(zhuǎn)錄。體外研究
BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.體內(nèi)研究
BMH-21 reduces tumor growth in mouse xenografts.