| Identification | Back Directory | [Name]
BMH21 | [CAS]
896705-16-1 | [Synonyms]
BMH21
CS-1749
BMH 21;BMH21
BMH-21, >98%
BMH21 USP/EP/BP
N-[2-(Dimethylamino)ethyl]-12-oxo-5,13-diazatetracene-4-carboxamide
N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-
BMH-21 N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide | [EINECS(EC#)]
809-833-1 | [Molecular Formula]
C21H20N4O2 | [MDL Number]
MFCD27225377 | [MOL File]
896705-16-1.mol | [Molecular Weight]
360.41 |
| Hazard Information | Back Directory | [Uses]
BMH-21 has been used in cell culture. | [General Description]
BMH-21 is a planar heterocyclic small molecule DNA intercalator. | [Biochem/physiol Actions]
BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines. | [storage]
Store at -20°C |
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