83701-22-8
中文名稱(chēng)
敏樂(lè)啶硫酸鹽
英文名稱(chēng)
Minoxidil sulphate
CAS
83701-22-8
分子式
C9H15N5O4S
MDL 編號(hào)
MFCD06248907
分子量
289.31
MOL 文件
83701-22-8.mol
更新日期
2024/12/20 09:16:40
83701-22-8 結(jié)構(gòu)式
基本信息
中文別名
6-(1-哌啶基)-2,4-嘧啶二胺-3-氧化物硫酸鹽6-氨基-1,2-二氫-1-羥基-2-亞胺基-4-(1-哌啶基)嘧啶硫酸酯
米諾地爾硫酸鹽
敏樂(lè)啶硫酸鹽
硫酸敏樂(lè)定
硫酸米諾地爾
英文別名
6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE-3-OXIDE SULFATEMINOXIDIL SULFATE
MINOXIDIL SULPHATE
U-58838
minoxidilsulfateester
MINOXIDIL SUFATE ETHYLATED
1,6-Dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-2-pyrimidinamine
Minoxidil O-sulfate
所屬類(lèi)別
原料藥：抗高血壓病藥物理化學(xué)性質(zhì)
熔點(diǎn)175-180°C
密度1.75±0.1 g/cm3(Predicted)
RTECS號(hào)UV6260494
儲(chǔ)存條件−20°C
溶解度可溶于丙酮（少許）、DMSO（少許）
酸度系數(shù)(pKa)-4.99±0.18(Predicted)
形態(tài)白色固體。
顏色白色至灰白色
穩(wěn)定性Light Sensitive - Protect from Light, Store in Freezer
InChIInChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
InChIKeyAGMYAAIWWVATKU-UHFFFAOYSA-N
SMILESC1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1
CAS 數(shù)據(jù)庫(kù)83701-22-8(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335-H302-H315-H319-H335
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類(lèi)別碼R22-R36/37/38
安全說(shuō)明S26-S36
WGK Germany3
應(yīng)用領(lǐng)域
用途1
Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14碌M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.常見(jiàn)問(wèn)題列表
用途
米諾地爾硫酸鹽為白色結(jié)晶性粉末，可用作降壓藥，生發(fā)劑醫(yī)藥中間體。生物活性
Minoxidil sulfate 是一種有效的 ATP 敏感的 K+ 通道 (K+ channel) 激動(dòng)劑，是米諾地爾的硫酸代謝物。Minoxidil sulfate 被認(rèn)為是一種血管擴(kuò)張?jiān)噭趧?dòng)物實(shí)驗(yàn)?zāi)Ｐ椭?，促進(jìn)頭發(fā)生長(zhǎng)。靶點(diǎn)
IC50: K channel
體外研究
Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.
Western Blot Analysis
| Cell Line: | Rat brain microvascular endothelial cells (RBMECs) |
| Concentration: | 0-100 μM |
| Incubation Time: | 15 mins, 30 mins, 1 hour, 2 hours, 4 hours |
| Result: | Induced RhoA activation and PKB phosphorylation at Ser-473. |