82058-16-0
82058-16-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T23091 英文別名
G6NSC 33994
4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}
(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylaMino)Methyl]phenol
4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylaMino)Methyl]phenol
Phenol, 4,4'-[(1E)-1,2-diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]-
(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI)
物理化學(xué)性質(zhì)
沸點(diǎn)524.7±45.0 °C(Predicted)
密度1.040±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度二甲基亞砜：≥25mg/mL
酸度系數(shù)(pKa)9.20±0.50(Predicted)
形態(tài)粉末
顏色白色至棕褐色
穩(wěn)定性可在-20°下的DMSO或乙醇溶液保存長(zhǎng)達(dá)1個(gè)月。
常見(jiàn)問(wèn)題列表
生物活性
NSC 33994 (G6) 是選擇性的 JAK2 抑制劑，其 IC50 值為 60 nM。靶點(diǎn)
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JAK2 60 nM (IC 50 , JAK2 Val617Phe kinase activity ) |
體外研究
NSC 33994 (G6) reduces the levels of phospho-JAK2 in both a dose- and time-dependent manner.
NSC 33994 (G6, 0-25 μM, 0-48 h) inhibits phospho-JAK2 (pY1007/pY1008) in a dose-dependent and time-dependent manner.