7421-40-1
7421-40-1 結(jié)構(gòu)式
基本信息
18β-甘草次酸半琥珀酸酯二鈉
卡柏若克索龍
甘珀酸鈉
CARBENOXOLONE DISODIUM SALT
CARBENOXOLONE SODIUM
18-beta-glycyrrhetinicacidhydrogensuccinate,disodiumsalt
20-beta)-3-bet
3-beta-hydroxy-11-oxoolean-12-en-30-oicacidhydrogensuccinate,disodiumsal
3-o-(beta-carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oicacid,disodium
disodiumglycyrrhetinylsuccina
duogastrone
glycyrrhetinicacidhydrogensuccinate,disodiumsalt
neogel
olean-12-en-29-oicacid,3-(3-carboxy-1-oxopropoxy)-11-oxo-,disodiumsalt,(
olean-12-en-30-oicacid,3-beta-hydroxy-11-oxo-,hydrogensuccinate,disodiums
pyrogastrone
sanodin
sodium3-beta-hydroxy-11-oxo-12-oleanen-30-oatesodiumsuccinate
sodiumcarbenoxolone
ulcus-tablinen
carbenoxolone disodium
disodium 4-(20-carboxylato-11-oxo-30-beta-norolean-12-en-3-yloxy)-4-oxobutyrate
物理化學(xué)性質(zhì)
7421-40-1(安全特性,毒性,儲運)
常見問題列表
IC50: human 11β-HSD; bacterial 3α, 20β-HSD; gap junction; Vaccinia virus
Carbenoxolone disodium (6-150 μM; pre-treatment 1 hour) inhibits Vaccinia virus (VACV) replication in a gap junction-independent in HaCaT cells, and it has toxicity effects on VACV-A5L-EGFP infected cells at 48?h.Carbenoxolone (30 μM; pre-treatment 1 hour) does not upregulate PP2A expression, but induces the late protein A27 expression in hacat cells.
Cell Viability Assay
| Cell Line: | HaCaT cells |
| Concentration: | 6 μM, 12 μM, 30 μM, 60 μM, 150 μM |
| Incubation Time: | Pre-treatment 1 hour |
| Result: | Had no toxicity until 48 hours at high dose in virus-infected cells. |
Western Blot Analysis
| Cell Line: | HaCaT cells |
| Concentration: | 30 μM |
| Incubation Time: | Pre-treatment 1 hour |
| Result: | Presented an obvious upregulation of A27. |
Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Diazepam) does not induce a muscle relaxant activity and shows muscle relaxant activity compared to normal saline, and this effect was more than diazepam in the traction test.Carbenoxolone (intraperitoneal injection; 100, 200 and 300 mg/kg; 30, 60 and 60 min before Pentylenetetrazole) significantly increases sleeping time and decreases latency in mice as a dose-dependent manner in Pentylenetetrazole (PTZ) Seizure model. The ED 50 value is 83.3 mg/kg (%95 CL:556.29).
| Animal Model: | Male BALB/c mice |
| Dosage: | 100, 200 and 300 mg/kg |
| Administration: | Intraperitoneal injection; 30, 60 and 60 min before Pentylenetetrazole |
| Result: | Significantly increased the sleeping time in mice. |