6398-98-7
中文名稱
阿莫地喹鹽酸鹽
英文名稱
Amodiaquin dihydrochloride dihydrate
CAS
6398-98-7
EINECS 編號(hào)
200-706-0
分子式
C20H24Cl3N3O
MDL 編號(hào)
MFCD00078857
分子量
428.78
MOL 文件
6398-98-7.mol
更新日期
2024/12/23 17:53:10
6398-98-7 結(jié)構(gòu)式
基本信息
中文別名
7-氯-4-(3'-二乙基氨基甲基-4'-羥基苯胺基)喹啉二鹽酸鹽阿莫地喹鹽酸鹽
鹽酸阿莫地喹
阿莫地喹
阿莫地喹鹽酸鹽
英文別名
4-[(7-CHLORO-4-QUINOLINYL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL DIHYDROCHLORIDE4-([7-chloro-4-quinolinyl]amino)-2-([diethylamino]methyl)phenol dihydrochloride dihydrate
4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol dihydrochloride
7-chloro-4-(3'-diethylaminomethyl-4'-hydroxyanilino)quinoline dihydrochloride
acrichin dihydrochloride
AMODIAQUIN DIHYDROCHLORIDE
amodiaquin dihydrochloride dihydrate
AMODIAQUINE DIHYDROCHLORIDE
AMODIAQUINE HCL
AMODIAQUINE HYDROCHLORIDE
AMODIAQUIN HYDROCHLORIDE
Amodiaquine hydrochloride USP24
AMODIAQUINE 2HCL DIHYDRATE
AMODIAQUINE DIHYDROCHLORIDE 2-HYDRATE
AMODIAQUIN DIHYDROCHLORIDE DIHYDATE
所屬類別
分析化學(xué)：分析標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
RTECS號(hào)GO7300100
儲(chǔ)存條件Inert atmosphere,Room Temperature
溶解度溶于DMSO或甲醇
形態(tài)neat
顏色White to Yellow to Orange
最大波長(zhǎng)(λmax)342nm(MeOH)(lit.)
Merck14,572
穩(wěn)定性Hygroscopic
CAS 數(shù)據(jù)庫(kù)6398-98-7(CAS DataBase Reference)
阿莫地喹鹽酸鹽價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | J64326 | 4-(7-氯-4-喹啉基氨基)-2-(二乙基氨基甲基)苯酚 二鹽酸鹽 二水合物,98% 4-(7-Chloro-4-quinolinylamino)-2-(diethylaminomethyl)phenol dihydrochloride dihydrate, 98% | 6398-98-7 | 5g | 405元 |
| 2024/11/08 | J64326 | 4-(7-氯-4-喹啉基氨基)-2-(二乙基氨基甲基)苯酚 二鹽酸鹽 二水合物,98% 4-(7-Chloro-4-quinolinylamino)-2-(diethylaminomethyl)phenol dihydrochloride dihydrate, 98% | 6398-98-7 | 25g | 1436元 |
| 2024/11/08 | 45520 | 阿莫地喹鹽酸鹽 Amodiaquine dihydrochloride dihydrate | 6398-98-7 | 5g | 761元 |
常見(jiàn)問(wèn)題列表
生物活性
Amodiaquine在人紅細(xì)胞中是一種有效的、非競(jìng)爭(zhēng)性的組胺N-甲基轉(zhuǎn)移酶抑制劑，其Ki值為18.6 nM。它也被用作抗瘧疾藥和消炎藥。靶點(diǎn)
| Target | Value |
|
histamine N-methyl transferase
(Cell-free assay) | 18.6 nM(Ki) |
體外研究
Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH
+
neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.
RT-PCR
| Cell Line: | Primary microglia |
| Concentration: | 10 μM, 15 μM, 20 μM |
| Incubation Time: | 4 hours |
| Result: | Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner. |
體內(nèi)研究
在狗的體內(nèi)實(shí)驗(yàn)中，小劑量的amodiaquine顯著地增強(qiáng)了組胺對(duì)胃液分泌的作用。對(duì) P. acnes-primed和LPS誘導(dǎo)的肝炎小鼠中，處理以amodiaquine，能有效阻止嚴(yán)重肝損傷和高致死性，增強(qiáng)了組胺的升高而不升高tele-methylhistamine (t-MeHA)。