625-08-1
625-08-1 結構式
基本信息
3-羥基-3-甲基丁酸
Α-羥異戊酸
3-HYDROXY-3-METHYLBUTANOIC ACID
3-HYDROXY-3-METHYL BUTYRIC ACID
BETA-HYDROXY-3-METHYL BUTYRIC ACID
BETA-HYDROXY BETA-METHYLBUTYRATE
BETA-HYDROXYISOVALERIC ACID
HMB
HYDROXYISOVALERIC ACID, BETA-
RARECHEM AL BO 2324
?Hydroxyisovaleric acid
β-Hydroxy-β-MethylButyric acid
(S)-2-Hydroxyisovaleric Acid
3-Hydroxyisovaleric acid
HYDROXY-METHYLBUTYRATE
SS-HYDROXYISOVALERIC ACID
3-HYDROXY-3-METHYL BUTYRIC ACID 98%
3-Methyl-3-hydroxybutanoic acid
β-Hydroxy-β-methylbutanoic acid
物理化學性質
DMSO:10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
安全數(shù)據(jù)
常見問題列表
向燒瓶中加入濃度為13.3重量％的次氯酸鈉水溶液347g(0.620mol)，冷卻，一邊保持在0℃-10℃一邊加入20.0g(0.172mol)雙丙酮醇，在0℃-10℃繼續(xù)攪拌15分鐘使雙丙酮醇與次氯酸鈉反應。
然后將反應物用鹽酸60.8g(0.600mol)酸化(pH：1.0)后，濃縮至殘留重量為125g(約為濃縮前重量的30％)，用乙酸乙酯(45mL×3次)萃取收集3-羥基-3-甲基丁酸(HMB)游離酸，3次萃取液的混合液濃縮得到HMB游離酸14.9g(以HMB換算為0.126mol)。
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Human Endogenous Metabolite
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The reduced activity of methylcrotonyl-CoA carboxylase (MCC) leads to an elevated excretion of 3-methylcrotonic acid, the product of its hydration (3-hydroxyisovaleric acid: 3-HIA), and 3-methylcrotonylglycine, formed by conjugation with glycine.
In male mice (ICR/Jcl) at 8 weeks of age fed the biotin-deficient diet for 6 weeks, the concentration of urinary 3-Hydroxyisovaleric acid is 114.2 mM creatinine, which is higher than the concentration of 35.2 mM creatinine in mice fed the biotin-deficient diet for 4 weeks.