566-65-4
中文名稱
氫化黃體酮
英文名稱
5-alpha-Dihydroprogesterone
CAS
566-65-4
EINECS 編號(hào)
209-297-3
分子式
C21H32O2
MDL 編號(hào)
MFCD00067132
分子量
316.48
MOL 文件
566-65-4.mol
更新日期
2024/10/28 09:58:50
566-65-4 結(jié)構(gòu)式
基本信息
中文別名
二氫黃體酮,5Α-孕甾-3,20-二酮,5-alpha-孕甾-3,20-二酮
二氫黃體酮
氫化黃體酮
英文別名
5A-DIHYDROPROGESTERONE5ALPHA-DIHYDROPROGESTERONE
5-ALPHA-PREGNAN-3,20-DIONE
5ALPHA-PREGNANE-3,20-DIONE (ALLO)
5A-PREGNAN-3,20-DIONE
5 A-PREGNANE-3 20-DIONE
(5S,8R,9S,10S,13S,14S,17S)-17-ACETYL-10,13-DIMETHYL-HEXADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
ALLOPREGNAN-3,20-DIONE
ALLOPREGNANDIONE
ALLOPREGNANE-3,20-DIONE
(5-alpha)-pregnane-20-dione
3,20-Allopregnanedione
3,20-Dioxo-5alpha-pregnane
5alpha-Pregnane-3,20-dione
5-beta-pregnane-3,20-dione
Pregnane-3,20-dione
Pregnane-3,20-dione, (5alpha)-
5A-pregnane-3-20-dione-allo
5alpha-Pregnan-3,20-dione-1,2,4,5,6,7-D6
5α-dihydroprogesterone
所屬類別
無(wú)機(jī)化工：氫化物物理化學(xué)性質(zhì)
熔點(diǎn)200 °C
沸點(diǎn)429.2±38.0 °C(Predicted)
密度1.048±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度氯仿（微溶）、乙酸乙酯（微溶）
形態(tài)固體
顏色白色至灰白色
InChIInChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14?,16-,17+,18-,19-,20-,21+/m0/s1
InChIKeyXMRPGKVKISIQBV-CVHNGYJVSA-N
SMILESC1(=O)CC2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@H](C(=O)C)CC3)CC2
CAS 數(shù)據(jù)庫(kù)566-65-4(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息3,20-Allopregnanedione(566-65-4)
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表
概述
氫化黃體酮是是由婦科常用藥物黃體酮?dú)浠玫健?/span>特征鑒別
一.17位有甲基酮結(jié)構(gòu)，可與高鐵離子絡(luò)合顯色。例如與亞硝基鐵氰化鈉反應(yīng)顯藍(lán)紫色。 二.3位羰基，可與異煙肼反應(yīng)生成腙顯黃色。參考文獻(xiàn)
[1]http://baike.baidu.com/link?url=FMosnY9Y5-bbwPJ-EjViVsLQExIIwpo5sulvGas8fKkIKyie2unLHfLEtId2KWGwzngbb_rWlA25BAn2NuwW-Y5KSrwl9phWBlZhlkhIbTuV0mZthwHqlZOx2TGvBYgMYNmfeIKrAC1Z0zG3ACsLl生物活性
5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) 是一種內(nèi)源性的孕酮代謝物。5a-Pregnane-3,20-dione 可使肌動(dòng)蛋白actin解聚，并降低 actin 和 vinculin 的表達(dá)。5a-Pregnane-3,20-dione 可通過(guò)影響粘附和細(xì)胞骨架分子來(lái)參與促進(jìn)乳腺瘤形成和轉(zhuǎn)移。靶點(diǎn)
| Target | Value |
|
actin
() | |
|
vinculin
() |
體外研究
5a-Pregnane-3,20-dione decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerizes F-actin in MCF-7 breast cancer cells.