56-59-7
56-59-7 結(jié)構(gòu)式
基本信息
2-苯丙氨酸-8-賴氨酸加壓素
H-CYS-PHE-PHE-GLN-ASN-CYS-PRO-LYS-GLY-NH2, CYS1,6, CYCLIC
[PHE2,LYS8]-VASOPRESSIN
2-L-Phenylalanine-8-L-lysine-vasopressin
N-[5-Amino-1-(carbamoylmethylcarbamoyl)pentyl]-1-[19-amino-13,16-dibenzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
2-(phenylalanine)-8-lyine vasopression
Octapressin
Phelypressin
PLV-2
M.W. 1040.22 C46H65N13O11S2
(2-L-Phenylalanine)-8-lysinevasopressin
2-(Phenylalanine)-8-lysine vasopressin
L-Cys(1)-L-Phe-L-Phe-L-Gln-L-Asn-L-Cys(1)-L-Pro-L-Lys-Gly-NH2
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
不良反應(yīng)和禁忌：用藥后可有面色和皮膚蒼白、尿意、腹痛、腹瀉、脈搏減慢等癥狀；過量會(huì)惡心、嘔吐。冠狀動(dòng)脈患者忌用，孕婦和老人慎用。
常見問題列表
Vasopressin 1
Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells.
Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure.
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors.