407-41-0
基本信息
右磷絲氨酸
L-O-磷酸絲氨酸
H-SER(PO3H2)-OH
H-SER(P)-OH
L-2-AMINO-3-HYDROXYPROPANOIC ACID 3-PHOSPHATE
L-O-PHOSPHOSERINE
L-PHOSPHOSERINE
L-SERINE-O-PHOSPHATE
O-PHOSPHO-L-SERINE
O-PHOSPHORYL-L-SERINE
PHOSPHOSERINE
PHOSPHOSERINE ANTIBODY INHIBITOR
SERINE(PO3H2)-OH
dexfosfoserine
L-(+)-serine 3-(dihydrogen phosphate)
L-Phosphoserine Anhydrous
Phosphoserinebariumsalt
O-phosphoserine
Serine phosphate
(2S)-2-amino-3-phosphonooxy-propanoic acid
L-O-(RG)
物理化學(xué)性質(zhì)
知名試劑公司產(chǎn)品信息
L-O-Phosphoserine,>98.0%(T)(407-41-0)
常見問題列表
Target | Value |
mGluR
() |
O-Phospho-L-serine (l-SOP) weakly binds to mGluR1, and antagonizes the effects of l-glutamate. l-SOP activates the group III receptors (mGluR4, mGluR6, mGluR7, and mGluR8), but mGluR7 has much lower affinity for l-SOP than the other group III receptors and also displays lower efficacy for both ligands. O-Phospho-L-serine (l-SOP) generates enhanced intracellular calcium responses in mGluR4 transfected cells. l-SOP inhibits the l-glutamate mediated mGluR1 response, with a K i of 1 mM; l-SOP displays a substantially more potent inhibition of mGluR2 activation, with a K i of 1 μM, three orders-of-magnitude more potent than for mGluR1. l-SOP induces membrane potential changes in HEK/TRPC4 cells transfected with mGluR4 or mGluR6. l-SOP induces TRPC4β activation mediated by Gα i/o proteins. O-Phospho-L-serine (L-SOP) inhibits Müller glia proliferation, without affecting light-induced photoreceptor cell death. L-SOP disrupts Müller glia proliferation subsequent to or in parallel with the activation of ascl1a and stat3 expression in the light-damaged retina. L-SOP inhibits cone cell regeneration in the light-damaged retina.