23180-57-6
中文名稱
芍藥苷
英文名稱
Paeoniflorin
CAS
23180-57-6
EINECS 編號
245-476-2
分子式
C23H28O11
MDL 編號
MFCD00869331
分子量
480.46
MOL 文件
23180-57-6.mol
更新日期
2025/01/07 18:56:27
23180-57-6 結(jié)構(gòu)式
基本信息
中文別名
芍藥甙芍藥苷
英文別名
ACLITAXELNSC 178886
peoniflorin
Delmacinone
Paeony root
Paeoniflorm
PAEONIFLORIN
Paeonia moutan
PAEONIFLORIN(P)
Paeoniflorin std.
Paeoniflorin ,98%
Paeoniflorin P.E.
3aα,5α, 5aα,5bα)]-
Paeoniflorin Extract
White Peony Root P.E.
Paeonia lactiflora P.E.
PAEONIFLORIN 98+% BY HPLC
5-alpha,5a-alpha,5b-alpha))-a-alph
Ramipril (DMF, under registration)
Ranitidine (DMF, under registration)
Levofloxacin DMF (under registration)
Methylprednisolone Acetate, Micronized
PACLITAXEL C13 SOLUTION STD 1.0mg/mL(P)
β-D-Glucopyranoside,5b-[(benzoyloxy)methyl]
Paeoniflorin, froM Paeonia sterniana Fletcher in Journ.
5-methano-1h-3,4-dioxacyclobuta(cd)pentalen-1a(2h)-yl,(1ar-(1a-alpha,2-beta,3
beta-d-glucopyranoside,5b-((benzoyloxy)methyl)tetrahydro-5-hydroxy-2-methyl-2,
tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl,[1aR-(1aα,2β
(2R,6aβ)-3aβ-(Benzoyloxymethyl)-4-(β-D-glucopyranosyloxy)-5-methyl-2α,5α:3α,4α-dimethanohexahydrofuro[2,3-b]furan-2-ol
5beta-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1alpha(2H)-yl-beta-D-glucopyranoside
5beta-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1h-3,4-dioxacyclobuta[cd]pentalen-1alpha(2h)-yl-beta-d-glucopyranoside
(1aR,2S,3aR,5R,5aR,5bS)-5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl-β-D-glucopyranoside
[(1aR)-5bβ-[(Benzoyloxy)methyl]-3aβ,5,5aβ,5b-tetrahydro-5β-hydroxy-2β-methyl-2,5-methano-3,4-dioxa-1H-cyclobuta[cd]pentalen-1a(2H)-yl]β-D-glucopyranoside
[(1aR)-5bβ-[(Benzoyloxy)methyl]-3aβ,5,5aβ,5b-tetrahydro-5β-hydroxy-2-methyl-2α,5α-methano-3,4-dioxa-1H-cyclobuta[cd]pentalen-1aβ(2H)-yl]β-D-glucopyranoside
β-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-
beta-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aalpha,2beta,3aalpha,5alpha,5aalpha,5balpha)]-
beta.-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1a.alpha.,2.beta.,3a.alpha.,5.alpha.,5a.alpha.,5b.alpha.)]
所屬類別
生物化工：植物提取物物理化學(xué)性質(zhì)
外觀性質(zhì)白色吸濕性無定形粉末。
外觀性狀白色結(jié)晶，溶于甲醇，來源于牡丹皮、芍藥、赤芍。
熔點approximate 124℃ (dec.)
沸點498.51°C (rough estimate)
密度1.3044 (rough estimate)
折射率1.5376 (estimate)
儲存條件2-8°C
溶解度甲醇（微溶，超聲處理），吡啶（微溶）
酸度系數(shù)(pKa)11.52±0.70(Predicted)
形態(tài)粉末
顏色白色
InChIKeyYKRGDOXKVOZESV-WRJNSLSBSA-N
CAS 數(shù)據(jù)庫23180-57-6(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞警告
危險性描述H315-H319-H226
安全說明24/25
WGK Germany3
RTECS號RT1200000
海關(guān)編碼29389090
毒性LD50 ipr-mus: 9530 mg/kg YKKZAJ 89,879,69
應(yīng)用領(lǐng)域
用途一
抗心肌缺血、抑制血小板聚集作用；解痙作用；鎮(zhèn)痛、鎮(zhèn)靜作用；抗炎、抗?jié)冏饔?；保肝作用；調(diào)節(jié)免疫力作用；耐缺氧作用等。臨床應(yīng)用：用于冠心病的治療；用于老年性疾病，增強體質(zhì)與免疫功能、抗炎止咳、祛痰平喘等方面，尤其是老年慢性呼吸道疾病的治療中可作輔助藥物。常見問題列表
應(yīng)用
芍藥苷可抗組織細胞氧化應(yīng)激損傷、抑制星形膠質(zhì)細胞的激活、增強保護神經(jīng)，對于紋狀體及黑質(zhì)多巴胺能神經(jīng)細胞的損傷具有明顯的拮抗作用，并可改善運動遲緩，因而可用于治療阿爾茨海默癥、帕金森病、癲癇等腦部疾病。此外，芍藥苷還可以抗腫瘤、類風(fēng)濕關(guān)節(jié)炎和強直性脊柱炎等自身免疫性疾病。動物實驗還證明芍藥苷可明顯降低血糖含量、對心肺細胞具有重要的保護作用。制備
稱取40kg白芍藥材，用70％乙醇浸泡過夜，回流提取2次，每次2h，濾過，合并濾液，旋轉(zhuǎn)蒸發(fā)至無醇味，調(diào)整藥液使每1ml藥液相當(dāng)于0.5g生藥，備用。稱取120kg(濕重)LX38樹脂，裝入不銹鋼柱(300×2300cm)中，柱體積為60L，上樣，吸附1h后，先用水300L，10％乙醇300L去除雜質(zhì)，再用50％乙醇360L洗脫芍藥苷和白芍苷，最后用95％乙醇再生樹脂，流速為150?200L/h，將50％乙醇部位濃縮蒸干得2.52kg，其中芍藥苷純度為24％，白芍苷為16％。