201038-74-6
中文名稱
SB 269970鹽酸鹽
英文名稱
SB 269970 HYDROCHLORIDE
CAS
201038-74-6
分子式
C18H28N2O3S
分子量
352.49
MOL 文件
201038-74-6.mol
更新日期
2024/06/07 17:53:07
201038-74-6 結(jié)構(gòu)式
基本信息
中文別名
SB 269970鹽酸鹽(R)-1-[(3-羥基苯基)磺?；鵠-2-[2-(4-甲基-1-哌啶基)乙基]吡咯烷
英文別名
CS-776SB269970HCl
SB-269970
SB 269970
SB 269970 HYDROCHLORIDE
(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol
Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-
(R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine
Pyrrolidine, 1-((3-hydroxyphenyl)sulfonyl)-2-(2-(4-methyl-1-piperidinyl)ethyl)-, (R)-
(2R)-1-[(3-HYDROXYPHENYL)SULFONYL]-2-[2-(4-METHYL-1-PIPERIDINYL)ETHYL]PYRROLIDINE HYDROCHLORIDE
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點512.9±56.0 °C(Predicted)
密度1.188
儲存條件Inert atmosphere,2-8°C
溶解度H2O: 22 mg/mL
酸度系數(shù)(pKa)8.88±0.10(Predicted)
形態(tài)solid
常見問題列表
生物活性
SB269970 是 5-HT7 受體拮抗劑，pKi 為 8.3，對于其它受體有大于 50 倍的選擇性。靶點
|
Human 5-HT 7 Receptor 8.3 (pKi) |
體內(nèi)研究
SB-269970 (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity.
| Animal Model: | male C57BL6/J mice |
| Dosage: | 3, 10, 30 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Significantly blocked amphetamine and ketamine-induced hyperactivity. |