187618-60-6
中文名稱
N'-[(2,3-二氫-2,2,4,6,7-五甲基苯并呋喃-5-基)磺?；鵠-N-芴甲氧羰基-D-精氨酸
英文名稱
Fmoc-D-Arg(Pbf)-OH
CAS
187618-60-6
分子式
C34H40N4O7S
MDL 編號(hào)
MFCD00237010
分子量
648.77
MOL 文件
187618-60-6.mol
更新日期
2025/01/25 08:39:55
187618-60-6 結(jié)構(gòu)式
基本信息
中文別名
N5-[[[(2,3-二氫-2,2,4,6,7-五甲基苯并呋喃-5-基)磺酰]氨基]亞氨甲基]-N2-芴甲氧羰基-D-鳥(niǎo)氨酸Nα-FMOC-Nω-PBF-D-精氨酸
保護(hù)精胺酸
芴甲氧羰酰-D-精氨酸(PBF)
N'-[(2,3-二氫-2,2,4,6,7-五甲基苯并呋喃-5-基)磺?；鵠-N-芴甲氧羰基-D-精氨酸
英文別名
MOC-D-ARG(PBF)FMOC-CYS(DMT)-OH
FMoc-D-HArg(pbf)
Fmoc-D-Srg(Pbf)-OH
FMOC-D-ARG(PBF)-OH
FMOC-D-ARGININE(PBF)
FMOC-NG-PBF-D-ARGININE
Fmoc-D-Arg(Pbf)-OH ,99%
Nα-Fmoc-Nω-Pbf-D-Arginine
N-ALPHA-FMOC-N-OMEGA-PBF-D-ARGININE
N-Alpha-9-Fluorenylmethoxycarbonyl-Ng-2,2,4,6
D-Ornithine,N5-[[[(2,3-dihydro-2,2,4,6,7-pentamet
FMoc-D-Arg(Pbf)-OH N-α-FMoc-N-ω-2,2,4,6,7-pentaMethyldihydro
N2-Fmoc-N6-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine
nα-fmoc-nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-d-arginine
FMOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-D-ARGININE
N-ALPHA-FMOC-N'-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE
N-ALPHA-FMOC-NG-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE
N-ALPHA-FMOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-D-ARGININE
N^a-FMoc-N^w-(2,2,4,6,7-pentaMethyl-2,3-dihydrobenzo[b]furan-5-ylsulfonyl)-D-arginine, 98%
N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NG-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE
Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-arginine, Nα-Fmoc-Nω-Pbf-D-arginine
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-D-arginine
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N'-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-OMEGA-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-D-ARGININE
N-Alpha-(9-Fluorenylmethoxycarbonyl)-N-Omega-2,2,4,6,7-Pentamethyldihydrobenzofuran-5-Sulfonyl-D-Arginine
Nalpha-[(9H-Fluoren-9-ylMethoxy)carbonyl]-NoMega-(2,2,4,6,7-pentaMethyldihydrobenzofuran-5-sulfonyl)-D-arginine
N'-[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-arginine
N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-ornithine
N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-ornithine
(R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)pentanoic acid
D- Ornithine, N5-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl) sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9- ylmethoxy)carbonyl]-
所屬類別
生物化工：精氨酸類衍生物物理化學(xué)性質(zhì)
密度1.37±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度Soluble in water or 1% acetic acid
酸度系數(shù)(pKa)3.83±0.21(Predicted)
形態(tài)powder to crystal
顏色White to Almost white
BRN9537282
InChIKeyHNICLNKVURBTKV-MUUNZHRXSA-N
CAS 數(shù)據(jù)庫(kù)187618-60-6(CAS DataBase Reference)
常見(jiàn)問(wèn)題列表
概述
N'-[(2,3-二氫-2,2,4,6,7-五甲基苯并呋喃-5-基)磺?；鵠-N-芴甲氧羰基-D-精氨酸為氨基酸衍生物，可用作醫(yī)藥中間體。制備
a6.在反應(yīng)釜中加入H-Arg(Pbf)-OH，水120L、THF，用Na2CO3調(diào)節(jié)PH＝8.5。
b6.逐漸加入Fmoc-Osu(芴甲氧羰酰琥珀酰亞胺)，控制溫度15-20℃，PH＝8-9以把Arg(Pbf) 反應(yīng)完，盡量避免Fmoc-Osu過(guò)量。
TLC點(diǎn)板跟蹤反應(yīng)情況，從加完Fmoc-Osu開(kāi)始計(jì)算，反應(yīng)時(shí)間6小時(shí)。
c6.純化：用石油醚/乙酸乙酯(2:1)萃取；水相用HCl酸化至pH＝3，攪拌2小時(shí)。酸化溫度0-10℃；加乙酸乙酯萃取產(chǎn)品；用飽和食鹽水洗至pH達(dá)到6；無(wú)水硫酸鈉干燥，真空抽濾除去固體，濾液濃縮，減壓濃縮得到固體，真空干燥得到產(chǎn)品。
產(chǎn)品純度99.6％，最大單雜0.09％，L型異構(gòu)體0.15％。