1722-62-9
中文名稱
鹽酸甲哌卡因
英文名稱
Mepivacaine hydrochloride
CAS
1722-62-9
EINECS 編號(hào)
217-023-9
分子式
C15H22N2O
MDL 編號(hào)
MFCD00243006
分子量
246.35
MOL 文件
1722-62-9.mol
更新日期
2024/10/28 10:11:49
1722-62-9 結(jié)構(gòu)式
基本信息
中文別名
N-(2,6-二甲基苯基)-1-甲基-2-哌啶甲酰胺鹽酸鹽鹽酸甲哌卡因
低分子肝素
鹽酸卡波卡因
甲哌卡因鹽酸鹽
英文別名
1-methyl-2',6'-pipecoloxylidine hydrochloride1-METHYL-2',6'-PIPECOLOXYLIDINE HYDROCHLORIDE SALT
LABOTEST-BB LT00134661
MEPIVACAINE
MEPIVACAINE HCL
MEPIVACAINE HYDROCHLORIDE
n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride
N-(2,6-DIMETHYLPHENYL)-1-METHYL-2-PIPERIDINECARBOXAMIDE HYDROCHLORIDE SALT
(1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride
1-methyl-2’,6’-pipecoloxylididehydrochloride
6’-pipecoloxylidide,1-methyl-2monohydrochloride
carbocainehydrochloride
dl-1-methyl-2’,6’-pipecoloxylididehydrochloride
dl-mepivacainehydrochloride
n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamidmonohydrochloride
MEPIVACAINE HYDROCHLORIDE, USP
Mepivacaine HCl USP
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride
2',6'-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI, 8CI)
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (9CI)
所屬類別
原料藥：局部麻醉劑物理化學(xué)性質(zhì)
熔點(diǎn)255-257°C (dec.)
儲(chǔ)存條件2-8°C
溶解度在水中的溶解度為20mg/mL，澄清
形態(tài)粉末
顏色白色至米色
CAS 數(shù)據(jù)庫1722-62-9(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301-H336
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼R22
安全說明S22-S24/25
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1 / PGIII
RTECS號(hào)TK6475000
海關(guān)編碼29333990
毒性LD50 in mice, rats (mg/kg): 280, 500 s.c. (Aberg)
1722-62-9(安全特性,毒性,儲(chǔ)運(yùn))
儲(chǔ)運(yùn)特性
庫房低溫通風(fēng)干燥毒性分級(jí)
中毒急性毒性
腹腔-小鼠 LD50: 117 毫克/公斤; 靜脈-小鼠 LD50: 35 毫克/公斤可燃性危險(xiǎn)特性
熱分解排出有毒氮氧化物煙霧類別
有毒物質(zhì)滅火劑
水, 二氧化碳, 泡沫, 干粉鹽酸甲哌卡因價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-B0517A | 鹽酸甲哌卡因 Mepivacaine hydrochloride | 1722-62-9 | 500mg | 400元 |
| 2024/08/19 | HY-B0517A | 鹽酸甲哌卡因 Mepivacaine hydrochloride | 1722-62-9 | 10mM * 1mLin Water | 440元 |
| 2024/08/19 | HY-B0517A | 鹽酸甲哌卡因 Mepivacaine hydrochloride | 1722-62-9 | 1g | 600元 |
常見問題列表
生物活性
Mepivacaine 是一種叔胺，用作局部麻醉劑。體外研究
Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.
Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).
Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.
體內(nèi)研究
對(duì)馬的測(cè)試表明，與根據(jù)以前解剖的，乳膠注射后得到的假定相比，mepivacaine在相鄰關(guān)節(jié)結(jié)構(gòu)間具有更大的擴(kuò)撒，與關(guān)節(jié)造影研究形成對(duì)比。經(jīng)歷膝關(guān)節(jié)鏡檢查患者中，與神經(jīng)刺激相比較，超聲處理使1.5% mepivacaine阻斷坐骨神經(jīng)所需的最低有效麻醉劑體積(MEAV50)減少37%。在犬齒和前臼齒中，lidocaine制劑與腎上腺素相比，3%mepivacaine的使用使麻醉時(shí)間間隔更短。