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113-52-0

中文名稱 鹽酸丙咪嗪
英文名稱 Imipramine hydrochloride
CAS 113-52-0
EINECS 編號 204-030-7
分子式 C19H25ClN2
MDL 編號 MFCD00012669
分子量 316.87
MOL 文件 113-52-0.mol
更新日期 2023/03/20 15:41:21
113-52-0 結(jié)構(gòu)式 113-52-0 結(jié)構(gòu)式

基本信息

中文別名
N,N-二甲基-10,11-二氫-5H-二苯并[b,f]氮雜卓-5-丙胺鹽酸鹽
鹽酸丙咪嗪
丙咪嗪
咪帕明
托弗尼爾
丙咪嗪鹽酸
丙咪嗪鹽酸鹽
英文別名
10,11-dihydro-5-(3-(dimethylamino)propyl)-5h-dibenz[b,f]azepine hydrochloride
10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE
10,11-DIHYDRO-N,N-DIMETHYL-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE
IMIPRAMINE HCL
IMIPRAMINE HYDROCHLORIDE
LABOTEST-BB LT00452014
10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine
5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride
5H-dibenz[b,f]azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-,monohydrochloride
antideprinhydrochloride
chimoreptin
chrytemin
cocapimipramine25
deprinol
dynazina
efuranol
f)azepine,10,11-dihydro-5-(3-(dimethylamino)propyl)-5h-dibenz(hydrochlor
f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(monohydrochl
f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(monohydrochloride
f)azepine-5-propanamine,10,11-dihydro-n,n-dimethyl-5h-dibenz(monohydroch
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

外觀性狀白色或類白色結(jié)晶性粉末,無臭或幾乎無臭,遇光漸變色。
溶解性在水,乙醇或三氯甲烷中易溶,在乙醚中幾乎不溶。
熔點(diǎn)168-1700C
閃點(diǎn)9℃
儲存條件2-8°C
儲存條件2-8°C
溶解度H2O: 50 mg/mL
溶解度H2O:50 mg/mL
形態(tài)crystalline
形態(tài)crystalline
顏色white
顏色白色
PH值4.2~5.2(100g/l,25℃)
水溶解性溶于水
最大波長(λmax)260nm(lit.)
Merck13,4943
Merck14,4920
質(zhì)量標(biāo)準(zhǔn)中國藥典2000;BP2003;EP4;JP14;USP27
CAS 數(shù)據(jù)庫113-52-0(CAS DataBase Reference)
EPA Substance Registry System113-52-0(EPA Substance)
藥理作用鹽酸丙咪嗪(113-52-0)為三環(huán)類抗抑郁藥,適用于治療遲緩性的內(nèi)因性抑郁癥。主要作用在于阻斷中樞神經(jīng)系統(tǒng)對去甲腎上腺素和5-羥色胺這二種神經(jīng)遞質(zhì)的再攝取,從而使突觸間隙中這二種神經(jīng)遞質(zhì)濃度增高,發(fā)揮抗抑郁作用。鹽酸丙咪嗪(113-52-0)還有抗膽堿,抗1腎上腺素受體及抗H1組胺受體作用,但對多巴胺受體影響甚小。

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H300
危險(xiǎn)品標(biāo)志Xn,T,F
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼23/25-36/38-36/37/38-22
危險(xiǎn)品運(yùn)輸編號UN 1230 3/PG 2
危險(xiǎn)品運(yùn)輸編號UN 1230 3/PG 2
WGK Germany3
WGK Germany3
RTECS號HO1925000
TSCAYes
海關(guān)編碼2933995800
毒性LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe)

應(yīng)用領(lǐng)域

用途一
鎮(zhèn)靜安眠性抗組織胺及抗抑郁藥,治療精神抑郁癥及小兒遺尿癥。

制備方法

方法一
10,11-二氫-5-二苯并[b,f]氮雜卓(見14230)與甲苯、鈉氨一起加熱回流1h,冷至40-50℃,滴加1-氯-3-二甲氨基丙烷,再回流16h。冷卻,過濾,濾液水洗層,取甲苯層減壓蒸餾,回收甲苯后,收集210-230℃(0.67kPa)餾分,得米帕明堿,最后經(jīng)成鹽而得成品。
鹽酸丙咪嗪價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08I0971丙咪嗪鹽酸鹽
Imipramine Hydrochloride
113-52-0250MG190元
2024/11/08I0971丙咪嗪鹽酸鹽
Imipramine Hydrochloride
113-52-01g485元
2024/11/08HY-B1490鹽酸丙咪嗪
Imipramine hydrochloride
113-52-0100mg500元

常見問題列表

生物活性
Imipramine hydrochloride 抑制血清素轉(zhuǎn)運(yùn)蛋白(serotonin),IC50 值為 32 nM。Imipramine hydrochloride 可阻止胰酶的易位,抑制 MV 和外泌體的分泌。
靶點(diǎn)

IC50: 32 nM (serotonin)

體外研究

Depression-like behavior is often complicated by chronic pain. Antidepressants including imipramine are widely used to treat chronic pain, but the mechanisms are not fully understood. Imipramine (IC 50 =32 nM) and desipramine (IC 50 =160 nM) are found to be potent inhibitors of the human placental serotonin transporter.

體內(nèi)研究

Administration of imipramine reverses social avoidance behavior, significantly increasing the interaction time. 24 days of imipramine treatment in RSD mice significantly decreases stress-induced mRNA levels for IL-6 in brain microglia. Chronic mild stress induces a long-term altered gene expression profile in the prefrontal cortex that is partially reverted by imipramine treatment (10mg/kg, i.p.). Chronic imipramine administration alteres the amino acid dynamics in the brain. In the striatum, the concentrations of asparagine, glutamine and methionine are significantly increased by chronic imipramine administration. In the thalamus and hypothalamus, chronic imipramine administration significantly decreased the valine concentration. Imipramine reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-HT neurons and by anti-BDNF treatment. Imipramine also normalizes derangement of ERK/CREB coupling, which leads to induction of BDNF. This suggests a possible interaction between 5-HT and BDNF. Imipramine treatment counteracts the corticosterone administration-induced increase in the reactivity of rat CA3 hippocampal circuitry to the activation of the 5-HT receptor.

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