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11021-14-0

中文名稱 人參皂甙 Rc
英文名稱 Ginsenoside Rc
CAS 11021-14-0
EINECS 編號(hào) 234-253-5
分子式 C53H90O22
MDL 編號(hào) MFCD00133368
分子量 1079.27
MOL 文件 11021-14-0.mol
更新日期 2025/01/07 18:51:24
11021-14-0 結(jié)構(gòu)式 11021-14-0 結(jié)構(gòu)式

基本信息

中文別名
人參皂甙RC
人參皂苷RC
英文別名
GINSENOSIDE GINSENOSIDE-RC
GINSENOSIDE RC
20-[(6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
GINSENOSIDE FROM GINSENG ROOT (PANAX*QUI NQUEFOLIUM
ginsenoside-rc from panax quinquefolium (american ginseng)root
Ginsenoside Rc (CAS# 11021-14-0)
20-[(6-O-alpha-L-Arabinofuranosyl-beta-D-glucopyranosyl)oxy]-12b-hydroxydammar-24-en-3b-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
GINSENOSIDE RC WITH HPLC
arabinofuranosyl-β-D-glucopyranosyl)oxy]-12-
glucopyranosyl-
hydroxydammar-24-en-3-yl2-O-β-D-
Panaxoside Rc
[20-[(6-O-α-L-Arabinofuranosyl-β-D-glucopyranosyl)oxy]-12β-hydroxydammar-24-en-3β-yl]2-O-β-D-glucopyranosyl-β-D-glucopyranoside
3β-[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-20-[6-O-(α-L-arabinofuranosyl)-β-D-glucopyranosyloxy]dammara-24-ene-12β-ol
所屬類別
生物化工:提取物

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于人參根莖。
熔點(diǎn)199~201℃
沸點(diǎn)1128.3±65.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度DMSO(微量)、甲醇(微量)、吡啶(微量)
酸度系數(shù)(pKa)12.85±0.70(Predicted)
形態(tài)固體
顏色白色至淡黃色
檢測方法NMR,HPLC
穩(wěn)定性吸濕性
LogP5.100 (est)
CAS 數(shù)據(jù)庫11021-14-0(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
防范說明P301+P312+P330
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼R20/21/22
安全說明S26-S36
WGK Germany3
RTECS號(hào)LY9536300
海關(guān)編碼29389090

應(yīng)用領(lǐng)域

用途1
應(yīng)用于醫(yī)藥保健行業(yè),可以配制成抗疲勞、抗衰老以及健腦的保健食品;
用途2
人參皂苷Rc屬于甾體和三萜類皂苷,在參屬植物中獨(dú)有,有抑制或阻止腫瘤的生長特性。

知名試劑公司產(chǎn)品信息

人參皂甙 Rc價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-N0042人參皂甙 Rc
Ginsenoside Rc
11021-14-05mg650元
2024/11/08HY-N0042人參皂甙 Rc
Ginsenoside Rc
11021-14-010mg1100元
2024/11/08HY-N0042人參皂甙 Rc
Ginsenoside Rc
11021-14-010 mM * 1 mLin DMSO1306元

常見問題列表

生物活性
Ginsenoside Rc 是主要的人參皂甙之一,Ginsenoside Rc 增強(qiáng) GABA 受體 A (GABAA) 介導(dǎo)的離子通道 (IGABA)。 Ginsenoside Rc 還抑制 TNF-α 和 IL-1β 表達(dá)。
靶點(diǎn)

TNF-α

IL-1β

體外研究

Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptor A (GABA A )-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABA A receptor. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation.

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