63223-86-9
基本信息
人參皂苷-RH1
人參皂甙 Rh1
S-人參皂苷RH1
人參皂苷RH1(S)
人參皂苷 S-RH1
(R型)人參皂苷RH1
(S型)人參皂苷RH1
人參皂苷RH1(標準品)
人參皂苷RH1, 來源于人參
Sanchinoside B2
gensenoside Rh1
Prosapogenin A2
sanchinoside rh1
(S)Ginsenoside-Rh1
GINSENOSIDE Rh1(SH)
Ginsenoside Rh1 ,98%
Ginsenoside Rh1 (Prosapogenin A2
Ginsenoside Rh1, 98%, from Panax ginseng C. A. Mey.
物理化學性質(zhì)
常見問題列表
PPAR-γ
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TNF-α
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IL-6
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IL-1β
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Human Endogenous Metabolite
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The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected.
When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone.