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63223-86-9

中文名稱 人參皂甙 Rh1
英文名稱 Ginsenoside Rh1
CAS 63223-86-9
分子式 C35H60O9
分子量 624.85
MOL 文件 63223-86-9.mol
更新日期 2024/12/20 18:42:49
63223-86-9 結構式 63223-86-9 結構式

基本信息

中文別名
人參皂莢RH1
人參皂苷-RH1
人參皂甙 Rh1
S-人參皂苷RH1
人參皂苷RH1(S)
人參皂苷 S-RH1
(R型)人參皂苷RH1
(S型)人參皂苷RH1
人參皂苷RH1(標準品)
人參皂苷RH1, 來源于人參
英文別名
GINSENOSIDE RH1
Sanchinoside B2
gensenoside Rh1
Prosapogenin A2
sanchinoside rh1
(S)Ginsenoside-Rh1
GINSENOSIDE Rh1(SH)
Ginsenoside Rh1 ,98%
Ginsenoside Rh1 (Prosapogenin A2
Ginsenoside Rh1, 98%, from Panax ginseng C. A. Mey.
所屬類別
生物化工:提取物

物理化學性質(zhì)

外觀性狀白色粉末,可溶于甲醇、乙醇、DMSO等有機溶劑,來源于人參。
沸點755.1±60.0 °C(Predicted)
密度1.23
儲存條件Sealed in dry,2-8°C
溶解度DMSO : 100 mg/mL (156.53 mM; Need ultrasonic)
酸度系數(shù)(pKa)12.91±0.70(Predicted)
形態(tài)粉末
顏色白色
LogP3.740 (est)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302

應用領域

用途1
(20S)-人參皂苷Rh1是人參中的主要成分之一,具有抗炎作用。

常見問題列表

理化性質(zhì)
人參皂苷Rh1來源為五加科植物人參Panax ginseng C. A. Mey.的干燥根,是一種白色粉末狀物質(zhì),溶解性:易溶于水、甲醇、乙醇,不溶于乙/醚、苯。
生物活性
20(S)-Ginsenoside Rh1 (Prosapogenin A2, Sanchinoside B2, Sanchinoside Rh1)是從紅參中提取的主要生物活性化合物之一,在世界范圍內(nèi),紅參已越來越多地用于增強認知和身體健康。它具有抗發(fā)炎、抗氧化、免疫調(diào)節(jié)作用和對神經(jīng)系統(tǒng)有積極作用的有效特性。20(S)-Ginsenoside Rh1 可抑制 PPAR-γ、TNF-α、IL-6 和 IL-1β 的表達。
靶點

PPAR-γ

TNF-α

IL-6

IL-1β

Human Endogenous Metabolite

體外研究

The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected.

體內(nèi)研究

When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone.

人參皂甙 Rh1價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-N0604人參皂甙 Rh1
Ginsenoside Rh1
63223-86-95mg400元
2024/11/08HY-N0604人參皂甙 Rh1
Ginsenoside Rh1
63223-86-910mM * 1mLin DMSO560元
2024/11/08HY-N0604人參皂甙 Rh1
Ginsenoside Rh1
63223-86-910mg650元
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