| Identification | More | [Name]
Methyl chloroacetate | [CAS]
96-34-4 | [Synonyms]
AKOS BBS-00004061
CHLOROACETIC ACID METHYL ESTER
LABOTEST-BB LT00779142
METHYL CHLOROACETATE
METHYL ESTER CHLOROACETIC ACID
METHYL MONOCHLOROACETATE
METHYL MONOCHOROACETATE
Aceticacid,chloro-,methylester
Chloroaceticacidmetylester
chloro-aceticacimethylester
chloroethanoicacid,methylester
ClH2CCOOCH3
ethanoicacid,chloro-,methylester
Methyl chloroethanoate
Methyl ester of Chloroacetic acid
Methyl monochloracetate
methylalpha-chloroacetate
methylchloroethanoate
Methylester kyseliny chloroctove
methylesterkyselinychloroctove | [EINECS(EC#)]
202-501-1 | [Molecular Formula]
C3H5ClO2 | [MDL Number]
MFCD00000931 | [Molecular Weight]
108.52 | [MOL File]
96-34-4.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLOURLESS LIQUID | [Melting point ]
-33 °C | [Boiling point ]
130 °C740 mm Hg(lit.)
| [density ]
1.238 g/mL at 25 °C(lit.)
| [vapor density ]
3.8 (vs air)
| [vapor pressure ]
10 mm Hg ( 25 °C)
| [refractive index ]
n20/D 1.422(lit.)
| [Fp ]
125 °F
| [storage temp. ]
Flammables area | [solubility ]
51.6g/l (slow decomposition) | [form ]
Liquid | [color ]
Clear colorless | [PH]
4.6 (28g/l, H2O, 20℃) | [explosive limit]
4.6-18.5%(V) | [Water Solubility ]
28 g/L (20 ºC) | [Merck ]
14,6042 | [BRN ]
506255 | [Dielectric constant]
12.9（20℃） | [LogP]
0.63 at 20℃ | [CAS DataBase Reference]
96-34-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Acetic acid, chloro-, methyl ester(96-34-4) | [EPA Substance Registry System]
96-34-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi,F | [Risk Statements ]
R10:Flammable.
R23/25:Toxic by inhalation and if swallowed .
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R40:Limited evidence of a carcinogenic effect.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 2295 6.1/PG 1
| [WGK Germany ]
2
| [RTECS ]
AF9500000
| [F ]
19 | [Autoignition Temperature]
869 °F | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
I | [HS Code ]
29154000 | [Safety Profile]
Poison by ingestion.
Moderately toxic by inhalation and
subcutaneous routes. Flammable when
exposed to heat or flame; can react
vigorously with oxidizing materials. When
heated to decomposition it emits toxic
fumes of Cl-. | [Hazardous Substances Data]
96-34-4(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 107 mg/kg |
| Hazard Information | Back Directory | [General Description]
A crystalline solid or a solid dissolved in a liquid. Insoluble in water and denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals. | [Reactivity Profile]
METHYL CHLOROACETATE(96-34-4) is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. | [Air & Water Reactions]
Highly flammable. Insoluble in water. | [Hazard]
Toxic by ingestion and inhalation. | [Health Hazard]
Extremely corrosive to the eyes, skin, nose, throat, and upper respiratory tract. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. | [Fire Hazard]
Special Hazards of Combustion Products: Toxic fumes of hydrogen chloride | [Chemical Properties]
CLEAR COLOURLESS LIQUID | [Uses]
As solvent. | [Application]
Methyl chloroacetate (MC) is a halogenated ester mainly used as a solvent in organic synthesis or in the preparation of several compounds. Typically, MC is used in the preparation of (carboxymethyl) trimethylammonium chloride estersor in the synthesis of octakis- (carbethoxymethoxy)calix[8]arene. Additionally, methyl chloroacetate acts as an extraction solvent during the separation of neutral compounds with concentration enhancement using coupling liquid–liquid semi-microextraction with micellar electrokinetic chromatography through oncapillary decomposition. | [Preparation]
Methyl chloroacetate is prepared by esterification of chloroacetic acid with methanol.
Reaction: Methanol and chloroacetic acid are uniformly mixed in a weight ratio of 0.366:1, heated with stirring, and the esterification reaction is carried out at 105-110 °C. In the reaction process, the ternary azeotrope of methyl chloroacetate, water and methanol is continuously steamed, layered through the ester separator, the separated methanol and water are returned to the reaction pot, and the separated crude ester is made of sodium carbonate. neutralize. The neutralized crude ester is firstly cut out the 130°C fraction by atmospheric distillation, and then subjected to vacuum distillation to collect the 65°C (8kPa) fraction, which is the finished product of methyl chloroacetate. The yield is about 96%. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 50, p. 3408, 1985 DOI: 10.1021/jo00218a034 | [Purification Methods]
Shake the ester with saturated aqueous Na2CO3 (three times), aqueous 50% CaCl2 (three times), saturated aqueous NaCl (twice), dry (Na2SO4) and fractionally distil it. Very toxic. [Beilstein 2 IV 480.] |
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