| Identification | More | [Name]
Chloroacetic anhydride | [CAS]
541-88-8 | [Synonyms]
BIS(CHLOROACETIC)ANHYDRIDE
CHLOROACETIC ACID ANHYDRIDE
CHLOROACETIC ANHYDRIDE
MONOCHLOROACETIC ACID ANHYDRIDE
2-Chloroacetic anhydride
2-chloroaceticanhydride
Aceticacid,chloro-,anhydride
alpha,alpha’-dichloroaceticanhydride
Chloracetic anhydride
chloraceticanhydride
chloro-aceticacianhydride
Chloroacetyl anhydride
chloroacetylanhydride
chloroethanoicanhydride
Monochloroacetic anhydride
sym-dichloroaceticanhydride
CHLOROACETIC ANHYDRIDE, TECH., APPROX. 9 0%
Chloroaceticanhydride,97%
Chloroacetic anhydride, tech., 90%
Chloroacetic anhydride 97% | [EINECS(EC#)]
208-794-2 | [Molecular Formula]
C4H4Cl2O3 | [MDL Number]
MFCD00000929 | [Molecular Weight]
170.98 | [MOL File]
541-88-8.mol |
| Chemical Properties | Back Directory | [Appearance]
brownish semi-transparent crystals, chunks or low | [Melting point ]
51 °C | [Boiling point ]
203 °C | [density ]
1.449 | [vapor pressure ]
<0.75 mm Hg ( 20 °C)
| [refractive index ]
1.4730 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin | [form ]
Crystals, Chunks or Low Melting Mass | [color ]
brown
| [Sensitive ]
Moisture Sensitive | [Merck ]
14,2113 | [BRN ]
774533 | [Stability:]
Moisture Sensitive | [InChIKey]
PNVPNXKRAUBJGW-UHFFFAOYSA-N | [CAS DataBase Reference]
541-88-8(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
Acetic acid, chloro-, anhydride (541-88-8) |
| Safety Data | Back Directory | [Hazard Codes ]
C,T | [Risk Statements ]
R34:Causes burns.
R36/37:Irritating to eyes and respiratory system .
R43:May cause sensitization by skin contact.
R25:Toxic if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [F ]
10-19-21 | [Hazard Note ]
Highly Toxic/Corrosive/Lachrymator | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29159000 | [Hazardous Substances Data]
541-88-8(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Chemical Properties]
brownish semi-transparent crystals, chunks or low | [Uses]
In N-acetylation of amino acids in alkaline solution; preparation of cellulose chloroacetates. | [Preparation]
chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form. | [Purification Methods]
Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.] |
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