| Identification | More | [Name]
3-Picolyl chloride hydrochloride | [CAS]
6959-48-4 | [Synonyms]
3-(CHLOROMETHYL)PYRIDINE HYDROCHLORIDE
3-(CHLOROMETHYL)-PYRIDINIUM CHLORIDE
3-PICOLYL CHLORIDE HYDROCHLORIDE
3-(chloromethyl)-pyridinhydrochloride
3-chloromethyl-pyridinhydrochloride
3-pyridylmethylchloridehydrochloride
nci-c03838
3-Picolyl chloride HCl (65% in water)
3-Picolylchlorid Hydrochloride
3-Picolylchlorid Hydrochlorid
3-PicolylChlorideHcl
3-(Chloromethyl)PyridineHydrochloride98%
3-(Chloromethyl)Pyridine Hydrochloride 98%
Pyridine, 3-(chloromethyl)-, hydrochloride
3-CHLOROMETHYLPYRIDINEHYPOCHLORIDE
(CHLOROMETHYL)PYRIDINEHYDROCHLORIDE
3-PICOLYL CHLORIDE HYDROCHLORIDE 98+%
3-PICOLYLCHLORIDE 3-CHLOROMETHYL PYRIDINE
3-CHLOROMETHYLPYRIDINE HYDROCHLORIDE (3-PICOLYLCHLORIDE HYDROCHLORIDE)
3-(chloromethyl)pyridine hydrochloride ,99% | [EINECS(EC#)]
230-150-4 | [Molecular Formula]
C6H7Cl2N | [MDL Number]
MFCD00012818 | [Molecular Weight]
164.03 | [MOL File]
6959-48-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White to pale brown solid | [Melting point ]
137-143 °C(lit.) | [storage temp. ]
Store at RT. | [form ]
Crystalline Needles or Powder | [color ]
White to beige | [Water Solubility ]
>=10 g/100 mL at 19 ºC | [Sensitive ]
Hygroscopic | [Detection Methods]
HPLC | [BRN ]
3689156 | [InChI]
InChI=1S/C6H6ClN.ClH/c7-4-6-2-1-3-8-5-6;/h1-3,5H,4H2;1H | [InChIKey]
UZGLOGCJCWBBIV-UHFFFAOYSA-N | [SMILES]
C1(CCl)C=NC=CC=1.Cl | [CAS DataBase Reference]
6959-48-4(CAS DataBase Reference) | [EPA Substance Registry System]
6959-48-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,C,T | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R45:May cause cancer.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
2811 | [WGK Germany ]
3
| [RTECS ]
US7000000
| [F ]
3-10 | [Hazard Note ]
Corrosive | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29333999 | [Safety Profile]
Suspected carcinogen
with experimental carcinogenic data. Poison
by ingestion. Mutation data reported. When
heated to decomposition it emits very toxic
fumes of NOx and Cl-. | [Hazardous Substances Data]
6959-48-4(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
Yellow powder or yellow-tan solid with an irritating odor. | [Reactivity Profile]
3-(CHLOROMETHYL)PYRIDINE HYDROCHLORIDE(6959-48-4) is incompatible with strong oxidizing agents and strong bases. | [Air & Water Reactions]
Hygroscopic. Water soluble. | [Fire Hazard]
Flash point data for this chemical are not available; however, 3-(CHLOROMETHYL)PYRIDINE HYDROCHLORIDE is probably combustible. | [Chemical Properties]
White to pale brown solid | [Uses]
3-(Chloromethyl)pyridine Hydrochloride(6959-48-4) has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.
| [Application]
3-Picolyl chloride hydrochloride(6959-48-4) is an organic synthetic reagent for the preparation of N,N-bis(pyridin-2-ylmethyl)aniline ligands, 2-oxodihydroquinoline-3-carboxamide derivatives, and 3β-amino-tropane arylamide derivatives with atypical antipsychotic profiles. It is also used in the preparation of novel bifunctional anion exchange resins for nuclear waste treatment.
| [Synthesis]
Chloromethyl pyridine hydrochloride is the important industrial chemicals of various agricultural chemicals, medicine intermediate, Insecticides (tech) & Herbicides (tech), sterilant. A synthetic method of 3-(chloromethyl)pyridine hydrochloride (also known as 3-Picolyl chloride hydrochloride) comprises steps as follows: (1) 3-methylpyridine is taken as a raw material, water is taken as a solvent, and the 3-methylpyridine is oxidized into 3-picolinic acid with potassium permanganate, wherein the molar ratio of the 3-methylpyridine to the potassium permanganate is 1:(2.1-2.3), the oxidizing temperature is kept at 85-90 DEG C, heating is performed for 30 min, a reaction solution is adjusted to be acid after the reaction, and 3-picolinic acid is obtained after cooling and filtration; (2) the 3-picolinic acid and methanol react to produce methyl pyridine-3-carboxylate under the acid condition, and the molar ratio of the 3-picolinic acid to the methanol is 1:1.3; (3) the methyl pyridine-3-carboxylate is reduced to 3-pyridinemethanol; (4) the 3-pyridinemethanol reacts with thionyl chloride to produce a target product, namely, 3-(chloromethyl)pyridine hydrochloride, and the molar ratio of the 3-pyridinemethanol to the thionyl chloride is 1:(1.1-1.3).
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