| Identification | More | [Name]
Methylmagnesium chloride | [CAS]
676-58-4 | [Synonyms]
METHYLMAGNESIUM CHLORIDE
chloromethyl-magnesiu
METHYLMAGNESIUM CHLORIDE, 2.5M SOLUTIONIN BUTYL DIGLYME
METHYLMAGNESIUM CHLORIDE, 3.0M SOLUTION IN TETRAHYDROFURAN
METHYLMAGNESIUM CHLORIDE SOLUTION, ~3 M IN THF
METHYLMAGNESIUM CHLORIDE, 3.0M SOLUTION
Methylmagnesium Chloride 1.5 M In Butyl Diglyme
Methylmagnesium Chloride 1.5 M in n-Butyl Ether
Methylmagnesium Chloride 2.0 M In Diethyl Ether
Methylmagnesium Chloride 2.0 M In Tetrahydrofuran
Methylmagnesium Chloride 2.2 M In Butyl Diglyme
Methylmagnesium Chloride 3.0 M In Tetrahydrofuran
Methylmagnesiumchloride,3MinTHF
Methylmagnesium chloride, 22 wt% solution in tetrahydrofuran
METHYLMAGNESIUM CHLORIDE, 3 M in TETRAHYDROFURAN
METHYLMAGNESIUM CHLORIDE IN TFE
Magnesium, chloromethyl-
methylmagnesium chloride solution
methylmagnesium chloride, 3m in thf, packaged under argon in resealable chemseal
Methylmagnesium chloride, 3M in THF, packaged under Argon in resealable ChemSealTM bottles | [EINECS(EC#)]
211-629-7 | [Molecular Formula]
CH3ClMg | [MDL Number]
MFCD00000468 | [Molecular Weight]
74.79 | [MOL File]
676-58-4.mol |
| Chemical Properties | Back Directory | [Definition]
Available as a solutionin tetrahydrofuran. | [Appearance]
dark brown solution | [Boiling point ]
66 °C
| [density ]
1.013 g/mL at 25 °C
| [Fp ]
−1 °F
| [storage temp. ]
Flammables + water-Freezer (-20°C)e area | [solubility ]
Miscible with diethyl ether and tetrahydrofuran. | [form ]
Liquid | [color ]
Pale brown to dark green | [Water Solubility ]
reacts | [Sensitive ]
Air & Moisture Sensitive | [BRN ]
3587199 | [Exposure limits]
ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) | [Uses]
Alkylating agent in organic synthesis, Grignardreagent. | [CAS DataBase Reference]
676-58-4(CAS DataBase Reference) | [Storage Precautions]
Store under inert gas;Moisture sensitive;Air sensitive | [EPA Substance Registry System]
676-58-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable.
R14/15:Reacts violently with water, liberating extremely flammable gases .
R34:Causes burns.
R19:May form explosive peroxides.
R15:Contact with water liberates extremely flammable gases. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S30:Never add water to this product .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7/8:Keep container tightly closed and dry .
S33:Take precautionary measures against static discharges .
S29:Do not empty into drains .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 3399 4.3/PG 2
| [WGK Germany ]
1
| [F ]
1-3-10 | [Autoignition Temperature]
609 °F | [TSCA ]
Yes | [HazardClass ]
4.3 | [PackingGroup ]
I | [HS Code ]
29319090 | [Hazardous Substances Data]
676-58-4(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Hazard]
Flammable, dangerous fire and explosionrisk. | [Chemical Properties]
dark brown solution | [Application]
Methylmagnesium chloride solution (3 M in THF) undergoes 1,3-addition with dialdose derived nitrones to form N-benzylhydroxylamines. The reductive cleavage of the N-O bond of these N-benzylhydroxylamines results in N-benzylaminosugars, which are key moieties of bioactive compounds. It can also react with Garner type aldehydes to form the corresponding secondary alcohols. | [Preparation]
reaction of methyl chloride and magnesium in anhydrous diethyl ether, usually in the presence of an initiator. | [Reactions]
Methylmagnesium chloride can react with acidic hydrogen on oxygen, sulfur and alkyne carbon of compounds containing active hydrogen (such as water, alcohol, mercaptan, amine, amide, acid, sulfonic acid, etc.); Propyl bromide, etc.) undergoes a coupling reaction; it can react with oxygen and carbon dioxide, aldehydes, ketones, etc. |
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