| Identification | More | [Name]
METHYLMAGNESIUM BROMIDE | [CAS]
75-16-1 | [Synonyms]
BROMOMETHYLMAGNESIUM
METHYLMAGNESIUM BROMIDE
Methyl magnesium bromide(in ethyl ether)
bromomethyl-magnesiu
methyl-magnesiubromide(ethylethersolution)[qr]
methylmagnesium bromide sol.
METHYLMAGNESIUM BROMIDE, 1.0M SOLUTION I N BUTYL ETHER
METHYLMAGNESIUM BROMIDE SOL., ~3 M IN DI ETHYL ETHER
METHYLMAGNESIUM BROMIDE, 1.4M SOLUTION I N TOLUENE/TETRAHYDROFURAN(75:25)
METHYLMAGNESIUM BROMIDE, 3.0M SOLUTION I N DIETHYL ETHER
METHYLMAGNESIUM BROMIDE SOLUTION
Methylmagnesium Bromide 1.0 M In Butyl Diglyme
Methylmagnesium Bromide 1.0 M In n-Butyl Ether
Methylmagnesium Bromide 1.0 M In Tetrahydrofuran
Methylmagnesium Bromide 2.0 M In n-Butyl Ether
Methylmagnesium Bromide 2.0 M In Tetrahydrofuran/Toluene
Methylmagnesium Bromide 3.0 M In Diethyl Ether
Methylmagnesium bromide, 1.4M solution in toluene/THF
Methylmagnesium bromide, 1M solution in THF
Methylmagnesium bromide, 3M solution in diethyl ether | [EINECS(EC#)]
200-844-1 | [Molecular Formula]
CH3BrMg | [MDL Number]
MFCD00000041 | [Molecular Weight]
119.24 | [MOL File]
75-16-1.mol |
| Chemical Properties | Back Directory | [Definition]
Available in solution inether. | [Appearance]
light yellow or tan to dark brown solution | [Boiling point ]
78-80℃ | [density ]
1.035 g/mL at 25 °C
| [Fp ]
77 °F
| [storage temp. ]
water-free area | [form ]
Solution, may develop some turbidity precipitate | [color ]
Pale brown | [Water Solubility ]
Reacts with water. | [Sensitive ]
Air & Moisture Sensitive | [BRN ]
3535220 | [Exposure limits]
ACGIH: TWA 400 ppm; STEL 500 ppm
OSHA: TWA 400 ppm(1200 mg/m3)
NIOSH: IDLH 1900 ppm | [InChIKey]
AVFUHBJCUUTGCD-UHFFFAOYSA-M | [CAS DataBase Reference]
75-16-1(CAS DataBase Reference) | [Storage Precautions]
Light sensitive;Moisture sensitive;Store under inert gas | [EPA Substance Registry System]
Magnesium, bromomethyl- (75-16-1) |
| Safety Data | Back Directory | [Hazard Codes ]
C,F+,F | [Risk Statements ]
R12:Extremely Flammable.
R14:Reacts violently with water.
R19:May form explosive peroxides.
R22:Harmful if swallowed.
R34:Causes burns.
R66:Repeated exposure may cause skin dryness or cracking.
R67:Vapors may cause drowsiness and dizziness.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R10:Flammable.
R65:Harmful: May cause lung damage if swallowed.
R63:Possible risk of harm to the unborn child.
R48/20:Harmful: danger of serious damage to health by prolonged exposure through inhalation .
R14/15:Reacts violently with water, liberating extremely flammable gases .
R11:Highly Flammable. | [Safety Statements ]
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S62:If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
UN 3399 4.3/PG 1
| [WGK Germany ]
2
| [RTECS ]
OM3700000 | [F ]
1-3-10 | [TSCA ]
Yes | [HazardClass ]
4.3 | [PackingGroup ]
I | [HS Code ]
29319090 | [Safety Profile]
May ignite
spontaneously in air. A very dangerous fire
hazard when exposed to heat or flame; can
react vigorously with oxidizing materials.
When heated to decomposition it emits
acrid smoke and irritating fumes. | [Hazardous Substances Data]
75-16-1(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
A colorless cloudy solution in diethyl ether. Flash point-49°F. Vapors heavier than air. | [Reactivity Profile]
Organometallics, such as METHYL MAGNESIUM BROMIDE, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. | [Air & Water Reactions]
Highly flammable. Reacts with water or moisture in the air to form flammable methane gas. The heat from this reaction may be sufficient to ignite the produced methane [AAR 1991]. Unstable peroxides may form with exposure of the ether to air. This is a slow process. | [Hazard]
Flammable, dangerous fire and explosionrisk. | [Health Hazard]
Fire will produce irritating, corrosive and/or toxic gases. Inhalation of decomposition products may cause severe injury or death. Contact with substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution. | [Fire Hazard]
Flammable/combustible material. May ignite on contact with moist air or moisture. May burn rapidly with flare-burning effect. Some react vigorously or explosively on contact with water. Some may decompose explosively when heated or involved in a fire. May re-ignite after fire is extinguished. Runoff may create fire or explosion hazard. Containers may explode when heated. | [Chemical Properties]
Clear brown solution when properly stored | [Uses]
Grignard reagent in greener solvent, 2-methyltetrahydrofuran (2-MeTHF) | [Application]
Methylmagnesium bromide solution (3M in diethyl ether) be used to synthesize:
3(4R)-{3(2R,3S)-[4′-(1′-triphenylmethyl)imidazole]-2-bromo-1-oxobutyl)-4-phenyl2-oxazolidinone.
Benzyl 2-(2-oxopropyl)piperidine-1-carboxylate.
(R*, R*) 1-[1-(1-phenylethyl)pyrrolidin-2-yl]propan-2-one). | [Solubility in organics]
Solubility: MeMgBr (Methylmagnesium Bromide) and MeMgI sol Et2O; MeMgCl and MeMgBr sol THF. MgI2 precipitates when MeMgI is prepared in THF, leaving mainly Me2Mg in the solution; some MgCl2 generally precipitates when MeMgCl is prepared in Et2O, particularly if the solution lasts several days. All are insoluble in hydrocarbons.
|
|
|