| Identification | More | [Name]
BENACTYZINE HYDROCHLORIDE | [CAS]
57-37-4 | [Synonyms]
2-(DIETHYLAMINO)ETHYL BENZILATE HYDROCHLORIDE
2-DIETHYLAMINOETHYL DIPHENYLGLYCOLATE HYDROCHLORIDE
BENACTIZINE HCL
BENACTYZINE HYDROCHLORIDE
BENZILIC ACID 2-(DIETHYLAMINO)ETHYL ESTER HYDROCHLORIDE
BENZILIC ACID DIETHYLAMINOETHYL ESTER HYDROCHLORIDE
LABOTEST-BB LT00159462
2-(diethylamino)-ethanobenzilatehydrochloride
2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid
2-diethylaminoethylesterkyselinybenzilovehydrochlorid
aktozin
amisyl
amitakon
amizil
arkadin
ay-5406
ay5406-1
benactyzinechloride
benaktin
benzeneaceticacid,alpha-hydroxy-alpha-phenyl-,2-(diethylamino)ethylester, | [EINECS(EC#)]
200-324-4 | [Molecular Formula]
C20H26ClNO3 | [MDL Number]
MFCD00012624 | [Molecular Weight]
363.88 | [MOL File]
57-37-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
DD2800000
| [HS Code ]
2922.50.4000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Safety Profile]
Poison by ingestion,
intraperitoneal, subcutaneous, intradermal,
and intravenous routes. Human systemic
effects by ingestion of very small amounts:
toxic psychosis. Experimental reproductive
effects. When heated to decomposition it
emits very toxic fumes of NO, and HCl | [Toxicity]
LD50 orl-rat: 184 mg/kg TXAPA9 1,42,59 |
| Hazard Information | Back Directory | [Originator]
Suavitil,Merck Sharp and
Dohme,US,1957 | [Uses]
Benactyzine Hydrochloride is an antagonist of acetylcholine in the central and peripheral nervous system. Benactyzine Hydrochloride is used as an antispasmodic.
| [Manufacturing Process]
114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part
of metallic sodium were placed in a flask attached to a total-reflux variable
take-off fractionating column. The pressure was reduced to 100 mm and heat
was applied by an oil bath the temperature of which was slowly raised to
90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C).
When the distillation of the ethanol became slow, the bath temperature was
raised to 120°C. When the vapor temperature indicated distillation of the
amino alcohol the take off valve was closed and the mixture was refluxed for
one hour. At the end of this period the vapor temperature had dropped and
two more parts of ethanol were distilled, The remaining aminoalcohol was
slowly distilled for three hours. The pressure was then reduced to 20 mm and
the remainder of the aminoalcohol distilled at 66°C. During the reaction the
color of the solution changed from yellow to deep red. The residue was
dissolved in 500 parts of ether, washed once with dilute brine, and three times
with water, dried over sodium sulfate and finally dried over calcium sulfate.
500 parts of a saturated solution of HCl in absolute ether was added and the
resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a
slight excess and the precipitate again filtered. The combined precipitates
were washed with cold acetone. The 106 parts of product was purified by
recrystallization from acetone as fine white crystals which melt at 177°-
178°C. | [Therapeutic Function]
Tranquilizer; Anticholinergic | [storage]
Store at -20°C |
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