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57-37-4

中文名稱(chēng) 乙胺痙平
英文名稱(chēng) BENACTYZINE HYDROCHLORIDE
CAS 57-37-4
EINECS 編號(hào) 200-324-4
分子式 C20H26ClNO3
MDL 編號(hào) MFCD00012624
分子量 363.88
MOL 文件 57-37-4.mol
更新日期 2023/03/20 15:41:19
57-37-4 結(jié)構(gòu)式 57-37-4 結(jié)構(gòu)式

基本信息

中文別名
貝那替秦
苯羥乙胺鹽酸鹽
胃樂(lè)康
乙胺痙平
鹽酸貝那替秦
鹽酸苯那辛
鹽酸貝那替嗪
鹽酸苯乃嗪
英文別名
2-(DIETHYLAMINO)ETHYL BENZILATE HYDROCHLORIDE
2-DIETHYLAMINOETHYL DIPHENYLGLYCOLATE HYDROCHLORIDE
BENACTIZINE HCL
BENACTYZINE HYDROCHLORIDE
BENZILIC ACID 2-(DIETHYLAMINO)ETHYL ESTER HYDROCHLORIDE
BENZILIC ACID DIETHYLAMINOETHYL ESTER HYDROCHLORIDE
LABOTEST-BB LT00159462
2-(diethylamino)-ethanobenzilatehydrochloride
2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid
2-diethylaminoethylesterkyselinybenzilovehydrochlorid
aktozin
amisyl
amitakon
amizil
arkadin
ay-5406
ay5406-1
benactyzinechloride
benaktin
benzeneaceticacid,alpha-hydroxy-alpha-phenyl-,2-(diethylamino)ethylester,
所屬類(lèi)別
原料藥:胃腸解痙藥

物理化學(xué)性質(zhì)

外觀(guān)性狀白色或幾乎白色結(jié)晶性粉末。熔點(diǎn)177-181℃。25℃時(shí)100ml水中可溶解該品14.9g,幾乎不溶于乙醚。無(wú)臭,味微苦。其堿基([302-40-9])熔點(diǎn)51℃。
熔點(diǎn)177-179 °C(lit.)
儲(chǔ)存條件Keep in dark place,Sealed in dry,Room Temperature
溶解度DMSO(微溶,加熱)、甲醇(微溶)
形態(tài)固體
顏色Crystals from Me2CO
Merck1029
CAS 數(shù)據(jù)庫(kù)57-37-4(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H301
危險(xiǎn)品標(biāo)志T
危險(xiǎn)類(lèi)別碼R23/24/25
安全說(shuō)明S36/37/39-S45
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 3
WGK Germany3
RTECS號(hào)DD2800000
海關(guān)編碼2922.50.4000
危險(xiǎn)等級(jí)6.1(b)
包裝類(lèi)別III
毒性LD50 orl-rat: 184 mg/kg TXAPA9 1,42,59

應(yīng)用領(lǐng)域

用途一
抗膽堿藥。

制備方法

方法一
由二苯乙醇酸與1-氯-2二乙氨基乙烷反應(yīng)得到。將甲苯、二苯乙醇酸和1-氯-2-二乙氨基乙烷在反應(yīng)鍋內(nèi)加熱回流3h,冷卻結(jié)晶,甩濾得到的粗品經(jīng)精制即為該品。

57-37-4(安全特性,毒性,儲(chǔ)運(yùn))

儲(chǔ)運(yùn)特性
通風(fēng)低溫干燥; 與庫(kù)房食品原料分開(kāi)存放
毒性分級(jí)
高毒
急性毒性
口服-大鼠 LD50; 184 毫克/公斤; 口服-小鼠 LD50: 160 毫克/公斤
可燃性危險(xiǎn)特性
燃燒產(chǎn)生有毒氮氧化物和氯化氫煙霧;極少量服用則精神失常
類(lèi)別
有毒物品
滅火劑
干粉,泡沫,沙土,二氧化碳, 霧狀水

知名試劑公司產(chǎn)品信息

乙胺痙平價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/08/19HY-B1542A乙胺痙平
Benactyzine hydrochloride
57-37-4100mg500元
2024/08/19HY-B1542A乙胺痙平
Benactyzine hydrochloride
57-37-410mM * 1mLin DMSO550元
2024/08/19B0053鹽酸貝那替嗪
Benactyzine Hydrochloride
57-37-45G150元

常見(jiàn)問(wèn)題列表

生物活性
Benactyzine hydrochloride是中樞性毒蕈堿受體拮抗劑。在抑郁癥和相關(guān)焦慮的治療中,它被用作抗抑郁劑。
靶點(diǎn)
TargetValue
Muscarinic receptor
()
體外研究

Benactyzine hydrochloride and drofenine are widely used anticholinergic drugs which are also competitive inhibitors of BChE with K i values of 0.010±0.001 and 0.003±0.000 mM, respectively. Results indicate that the inhibition of BChE by Benactyzine hydrochloride is pure or partial competitive. Pure competitive inhibition can be distinguished from partial competitive inhibition by plotting v vs [Benactyzine] at a fixed [BTCh].

體內(nèi)研究

Benactyzine hydrochloride (1 mg/kg) does not influence the attention response. Benactyzine hydrochloride increases the duration of the exploratory-motor reaction, but slightly diminishes the salivation elicited by acetylcholine. There is no blocking effect of Benactyzine hydrochloride and promazine on the EEG-seizure activity elicited by acetylcholine, and almost no inhibitory effect on emotional reactions. Emotional reactions are blocked by high doses of imipramine and promazine, but not by Benactyzine hydrochloride. The data indicates that imipramine, promazine and Benactyzine hydrochloride influence the autonomic effects of serotonin in different ways. Promazine, and especially Benactyzine hydrochloride, inhibit and shorten the period of salivation elicited by the intra-amygdaloid injection of serotonin.

"57-37-4" 相關(guān)產(chǎn)品信息
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