| Identification | More | [Name]
Ticlopidine hydrochloride | [CAS]
53885-35-1 | [Synonyms]
5-(2-CHLORO-BENZYL)-4,5,6,7-TETRAHYDRO-THIENO[3,2-C]PYRIDINE
5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine hydrochloride
5-[O-CHLOROBENZYL]-4,5,6,7-TETRAHYDRO-THIENO[3,2-C]PYRIDINE HYDROCHLORIDE
5-[O-CHLOROBENZYL]-4,5,6,7-TETRAHYDROTHIENOL[3,2-C]PYRIDINE HYDROCHLORIDE
TICLOPIDINE
TICLOPIDINE HCL
TICLOPIDINE HYDROCHLORIDE
2-c)pyridine,4,5,6,7-tetrahydro-5-(o-chlorobenzyl)-thieno(hydrochloride
2-c)pyridine,5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-thieno(hydroc
4-c-32
53-32c
panaldine
ticlid
ticlodix
ticlodone
5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridinium chloride
ticlodipine hydrochloride
Anagregal, Caudaline, Panaldine, Ticlid, Ticlodix, 5-[(2-Chlorophenyl)-methyl]-4,5,6,7-tetrahydrothienol[3,2-C]pyridine
5-(o-Chlorbenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridiniumchlorid
tiklid | [EINECS(EC#)]
258-837-4 | [Molecular Formula]
C14H14ClNS | [MDL Number]
MFCD00661081 | [Molecular Weight]
263.79 | [MOL File]
53885-35-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
205°C | [density ]
1.37 g/cm3 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Sparingly soluble in water and in anhydrous ethanol, very slightly soluble in ethyl acetate. | [form ]
neat | [pka]
7.64(at 25℃) | [color ]
White | [Water Solubility ]
Soluble to 100 mM in water and to 100 mM in DMSO. | [Usage]
An antithrombotic. a platelet aggregation inhibitor | [λmax]
295nm(H2O)(lit.) | [Merck ]
14,9421 | [CAS DataBase Reference]
53885-35-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
XJ9089100
| [HS Code ]
2934990002 | [Toxicity]
LD50 in mice (mg/kg/24 hrs): 55 i.v.; >300 orally (Castaigne) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Originator]
Ticlid,Millot,France,1978 | [Uses]
An antithrombotic. a platelet aggregation inhibitor | [Uses]
mucolytic, antibacterial, surface active agent | [Manufacturing Process]
A solution of thieno[3,2-c]pyridine (13.5 g; 0.1 mol) and 2-chlorobenzyl
chloride (17.7 g) in acetonitrile (150 ml) is boiled during 4 hours.
After evaporation of the solvent, the solid residue consists of 5-(2-
chlorobenzyl)-thieno[3,2-c]pyridinium chloride which melts at 166°C
(derivative n° 30). This compound is taken up into a solution comprising
ethanol (300 ml) and water (100 ml). Sodium borohydride (NaBH4)(20 g) is
added portionwise to the solution maintained at room temperature. The
reaction medium is maintained under constant stirring during 12 hours and is
then evaporated. The residue is taken up into water and made acidic with
concentrated hydrochloric acid to destroy the excess reducing agent. The
mixture is then made alkaline with ammonia and extracted with ether. The
ether solution is washed with water, dried and evaporated. The oily residue is
dissolved in isopropanol (50 ml) and hydrochloric acid in ethanol solution is
then added thereto.
After filtration and recrystallization from ethanol, there are obtained 5-(2-
chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride crystals
(yield: 60%) having a melting point (Koefler block) of 190°C. | [Therapeutic Function]
Platelet aggregation inhibitor | [Biological Activity]
Selective P2Y 12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo . | [storage]
4°C, away from moisture |
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