| Identification | More | [Name]
Ethyl 6-chloronicotinate | [CAS]
49608-01-7 | [Synonyms]
6-CHLORONICOTINIC ACID ETHYL ESTER
ETHYL 6-CHLORONICOTINATE
6-Chloro Nitotinic acid Ethyl ester
6-Chloronicotinic acid ethyl ester (Ethyl-6-Chloronicotinate)
Ethyl6-chloronicotinate,97%
3-Pyridinecarboxylic acid, 6-chloro-, ethyl ester
ETHYL 6-CHLORONICOTINATE[FOR TAZAROTENE]
Ethyl 6-chloropyridine-3-carboxylate
ETHYL 2-CHLOROPYRIDINE-5-CARBOXYLATE
Ethyl 2-chloropyridine-3-carboxylate, 6-Chloronicotinic acid ethyl ester
Ethyl 6-chloropyridine-3-carboxylate ,98%
6-Chloro-3-pyridinecarboxylic acid ethyl ester | [EINECS(EC#)]
610-463-6 | [Molecular Formula]
C8H8ClNO2 | [MDL Number]
MFCD00082739 | [Molecular Weight]
185.61 | [MOL File]
49608-01-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
26-30 °C(lit.)
| [Boiling point ]
98 °C | [density ]
1.245±0.06 g/cm3(Predicted) | [refractive index ]
1.522 | [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
-1.95±0.10(Predicted) | [color ]
Colourless to Off-White Oil | [Detection Methods]
HPLC | [BRN ]
4742175 | [InChIKey]
ILDJJTQWIZLGPO-UHFFFAOYSA-N | [CAS DataBase Reference]
49608-01-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
White to light yellow solid or colorless to yellow liquid | [Uses]
Ethyl 6-chloropyridine-3-carboxylate (Ethyl 6-chloronicotinate) may be used in the preparation of ethyl 5-{[5-(1H-benzimidazol-2-yl)pyridin-2-yl]ethynyl}pyridine-2-carboxylate by reacting with 2-[6-(ethynyl)pyridin-3-yl]-1H-benzimidazole under microwave irradiation. | [Uses]
Ethyl 6-chloronicotinate is a nicotinic acid derivative used in the preparation of potent H3 receptor antagonists.
| [General Description]
Ethyl 6-chloropyridine-3-carboxylate (Ethyl-6-chloronicotinate, E-6-ClN) undergoes direct amidation on reacting with benzylamine in the presence lanthanum trifluoromethanesulfonate La(OTf)3. The structural and physicochemical properties of E-6-ClN have been investigated based on its spectroscopic data, time-dependent density functional theory and density of state diagrams. |
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