| Identification | More | [Name]
Ethyl chloroformate | [CAS]
541-41-3 | [Synonyms]
AKOS BBS-00004329
Carbonchloridic acid ethyl ester
CHLOROFORMIC ACID ETHYL ESTER
ECF
ETHOXYCARBONYL CHLORIDE
ETHYL CHLOROCARBONATE
ETHYL CHLOROFORMATE
Carbonochloridicacid,ethylester
carbonochloridicacidethylester
Cathyl chloride
cathylchloride
chlorameisensaeureaethylester
Chlorocarbonate D'ethyle
chlorocarbonated’ethyle
chlorocarbonated’ethyle(french)
Chlorocarbonic acid, ethyl ester
chlorocarbonicacidethylester
chloro-formicaciethylester
Choroformicester
Clhorameisensaeureaethylester | [EINECS(EC#)]
208-778-5 | [Molecular Formula]
C3H5ClO2 | [MDL Number]
MFCD00000644 | [Molecular Weight]
108.52 | [MOL File]
541-41-3.mol |
| Chemical Properties | Back Directory | [Appearance]
A colorless to light yellow liquid. Sharp,
pungent odor, similar to HCl. | [Melting point ]
-81 °C (lit.) | [Boiling point ]
93 °C (lit.) | [density ]
1.139 g/mL at 20 °C
| [vapor density ]
3.74 (vs air)
| [vapor pressure ]
3.42 psi ( 20 °C)
| [refractive index ]
n20/D 1.395(lit.)
| [Fp ]
57 °F
| [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Soluble), Ethyl Acetate (Slightly) | [form ]
Liquid | [color ]
White to off-white | [Odor]
Irritating; sharp, like hydrochloric acid. | [explosive limit]
3.7-12.6% (v/v) | [Water Solubility ]
decomposes | [Sensitive ]
Moisture Sensitive | [Merck ]
14,3784 | [BRN ]
385653 | [Dielectric constant]
11.3（20℃） | [Stability:]
Moisture Sensitive | [LogP]
1.440 (est) | [CAS DataBase Reference]
541-41-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Carbonochloridic acid, ethyl ester(541-41-3) | [EPA Substance Registry System]
541-41-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,T+ | [Risk Statements ]
R11:Highly Flammable.
R22:Harmful if swallowed.
R26:Very Toxic by inhalation.
R34:Causes burns. | [Safety Statements ]
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S33:Take precautionary measures against static discharges .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1182 6.1/PG 1
| [WGK Germany ]
1
| [RTECS ]
LQ6125000
| [F ]
10-19-21 | [Autoignition Temperature]
842 °F | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
I | [HS Code ]
29151300 | [Safety Profile]
Poison by ingestion,
inhalation, and intraperitoneal routes.
Moderately toxic by skin contact. Corrosive.
An eye, skin, and mucous membrane
irritant. A very dangerous fire hazard when
exposed to heat or flame; can react
vigorously with oxidzing materials. Reacts
with water or steam to produce toxic and
corrosive fumes. To fight fire, use CO2, dry
chemical. When heated to decomposition it
emits highly toxic fumes of Cl-. | [Hazardous Substances Data]
541-41-3(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
A colorless liquid with a pungent odor. Flash point 66°F. Very toxic by inhalation. Corrosive to metals and tissue. Vapors are heavier than air. Prolonged exposure to low concentrations or short exposure to high concentrations may have adverse health effects from inhalation. | [Reactivity Profile]
ETHYL CHLOROFORMATE(541-41-3) decomposes slowly in water to form ethanol, HCl, and CO2 Attacks many metals especially in humid atmosphere [Handling Chemicals Safely 1980. p. 476]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. | [Air & Water Reactions]
Highly flammable. Emits fumes containing HCl on contact with moist air. Decomposes exothermically but slowly in water. | [Hazard]
Flammable, dangerous fire risk. Strong irritant to eyes and skin. | [Health Hazard]
Inhalation causes mucous membrane irritation, coughing, and sneezing. Vapor causes severe lachrymation; liquid causes acid-type burns of eyes and skin, like those of hydrochloric acid. Ingestion causes severe burns of mouth and stomach. | [Potential Exposure]
Heavily used in industry for various
processes; in ore processing, photography, making other
chemicals including amines, carbamates, isocyanates; polymers, diethyl carbonate; nitriles, etc. | [Fire Hazard]
Special Hazards of Combustion Products: Toxic chlorine and phosgene gases may be formed in fires. | [First aid]
Inhalation: remove to fresh air; use artificial respiration if breathing has stopped; call a doctor; keep victim
quiet and administer oxygen if needed. Eyes: flush with
water for at least 15 min.; see a doctor. Skin: wash liberally
with water for at least 15 min., then apply dilute solution of
sodium bicarbonate or commercially prepared neutralizer.
Ingestion: do NOT induce vomiting; give large amount of
water; get medical attention | [Shipping]
UN1182 Ethyl chloroformate, Hazard class: 6.1;
Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid,
8-Corrosive material Inhalation Hazard Zone B | [Incompatibilities]
Highly flammable; Vapors may form
explosive mixture with air. Emits fumes containing HCl on
contact with moist air. Decomposes exothermically but
slowly in water. Ethyl chloroformate decomposes slowly in
water forming ethanol, hydrogen chloride and carbon dioxide. May react vigorously, possibly explosively, if mixed
with di-isopropyl ether or other ethers in the presence of
trace amounts of metal salts. Reacts with acids, alkalies,
amines, alcohols, oxidizers and water. Corrosive to metals
especially in the presence of moisture. | [Chemical Properties]
Ethyl chloroformate is a colorless to light yellow liquid that is corrosive and flammable. It is prepared from phosgene and ethanol. It has a sharp pungent odor, like hydrochloric acid, and it decomposes in water. It is miscible with alcohol, benzene, chloroform, and ether. | [Waste Disposal]
Use a licensed professional
waste disposal service to dispose of this material. All federal, state, and local environmental regulations must be
observed. Consult with environmental regulatory agencies
for guidance on acceptable disposal practices | [Uses]
Ethyl chloroformate (chloroformic acid ethyl ester) is used as a solvent in the photographic industry, and as a chemical intermediate in the production of various carbamates, and used in synthesis of dyes, drugs, veterinary medicines, herbicides, and insecticides. It is also used in the production of flotation agents for ores, as a stabilizer for PVC, and in the production of modified penicillins and heterocyclic compounds (Gerhartz, 1985).
Cathyl Chloride is used in the preparation of new inhibitors for β-homocysteine S-methyltransferase. Also used in the synthesis of a hexosaminidase inhibitor.
| [Preparation]
Ethyl chloroformate was used in the synthesis of nitrile oxides. It can be obtained synthetically by the reaction between phosgene and anhydrous ethanol.
Ethyl chloroformate is chlorinated in the rectifying zone of a distillation reactor to produce 1-chloroethyl chloroformate and 2-chloroethyl chloroformate. | [Flammability and Explosibility]
Highlyflammable | [Chemical Reactivity]
Reactivity with Water: Slow reaction with water, evolving hydrogen chloride (hydrochloric acid); Reactivity with Common Materials: Slow evolution of hydrogen chloride from surface moisture reaction can cause slow corrosion; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water, rinse with sodium bicarbonate or lime solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. | [Purification Methods]
Wash the ester several times with water, redistil it using an efficient fractionating column at atmospheric pressure and a CaCl2 guard tube to keep free from moisture [Hamilton & Sly J Am Chem Soc 47 435 1925, Saunders et al. J Am Chem Soc 73 3796 1951]. [Beilstein 3 IV 23.] LACHRYMATORY AND TOXIC. |
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