| Identification | Back Directory | [Name]
PAC1 | [CAS]
315183-21-2 | [Synonyms]
PAC1
DUSP2
CS-243
PAC1-R
ADCYAP1R1
PAC-1,PAC1
PAC-1 10MG
PAC 1, >=98%
Pac1 receptor
Pac1 receptors
PAC1 USP/EP/BP
PACAP receptor 1
PAC-1 >=98% (HPLC)
Procaspase activating coMpound 1
PAC-1, 98%, a procaspase-3 activatior
Dual specificity protein phosphatase 2
PAC 1 - Procaspase activating compound 1
Dual specificity protein phosphatase PAC-1
ANTI-DUSP2 (C-TERM) antibody produced in rabbit
Anti-DUSP2 (C-terminal) antibody produced in rabbit
(4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide
(E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide
4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide
PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide
4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
1-Piperazineacetic acid, 4-(phenylmethyl)-, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
PAC 1
4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1 | [Molecular Formula]
C23H28N4O2 | [MDL Number]
MFCD03302441 | [MOL File]
315183-21-2.mol | [Molecular Weight]
392.49 |
| Chemical Properties | Back Directory | [density ]
1.14 | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
solid | [pka]
8.82±0.40(Predicted) | [color ]
white | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months. |
| Hazard Information | Back Directory | [Description]
PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3 | [Uses]
PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM. | [Biological Activity]
Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively). | [storage]
+4°C | [References]
1) Putt et al. (2006), Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy; Nat. Chem. Biol., 2 543
2) Peterson et al. (2009), PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition; J. Mol. Biol., 388 144
3) Bolham et al. (2016), Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with diverse Chemotherapeutics; ACS Cent. Sci., 2 545 |
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