| Identification | Back Directory | [Name]
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL | [CAS]
10129-56-3 | [Synonyms]
PETCM
APOPTOSIS ACTIVATOR I
a-(Trichloromethyl)-4-pyridineethanol
α-(Trichloromethyl)-4-pyridineethanol
4-Pyridineethanol, α-(trichloromethyl)-
1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE
α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane | [Molecular Formula]
C8H8Cl3NO | [MDL Number]
MFCD00177920 | [MOL File]
10129-56-3.mol | [Molecular Weight]
240.51 |
| Chemical Properties | Back Directory | [Boiling point ]
342.2±37.0 °C(Predicted) | [density ]
1.465±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: 22 mg/mL, soluble
| [form ]
solid
| [pka]
12.07±0.20(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
PETCM is a caspace-3 activator in cell extracts. | [Definition]
ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines. | [Biological Activity]
petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1]. | [storage]
Room temperature | [References]
[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226. |
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Energy Chemical
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