| Identification | Back Directory | [Name]
AC-VDVAD-CHO | [CAS]
194022-51-0 | [Synonyms]
AC-VDVAD-CHO
AC-VAVAD-CHO
AC-VDVAD-ALDEHYDE
CASPASE 2 INHIBITOR
CASPASE INHIBITOR VIII
AC-VAL-ASP-ALA-ASP-CHO
AC-VAL-ASP-VAL-ASP-CHO
AC-VAL-ASP-VAL-ALA-ASP-CHO
CASPASE-2 INHIBITOR (ALDEHYDE)
AC-VAL-ASP-VAL-ALA-ASP-ALDEHYDE
N-ACETYL-VAL-ASP-VAL-ALA-ASP-CHO
AC-VAL-ASP-VAL-ALA-ASP-H (ALDEHYDE)
Acetyl-valyl-aspartyl-valyl-alanyl-aspartal
AC-VAL-ASP-VAL-ALA-ASP-ALDEHYDE (PSEUDO ACID)
ACETYL-L-VALYL-L-ASPARTYL-L-VALYL-L-ALANYL-L-ASPART-1-AL
L-Alaninamide, N-acetyl-L-valyl-L-α-aspartyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-
(3S)-3-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-carboxy-3-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid | [Molecular Formula]
C23H37N5O10 | [MDL Number]
MFCD01862574 | [MOL File]
194022-51-0.mol | [Molecular Weight]
543.57 |
| Chemical Properties | Back Directory | [Boiling point ]
996.6±65.0 °C(Predicted) | [density ]
1.272±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [form ]
solid | [pka]
4.19±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50: 46 and 15 nM)[1]. | [IC 50]
Caspase-2: 46 nM (IC50); Caspase-3: 15 nM (IC50) | [References]
[1] Maillard MC, et al. Exploiting differences in caspase-2 and -3 S? subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Bioorg Med Chem. 2011 Oct 1;19(19):5833-51. DOI:10.1016/j.bmc.2011.08.020 |
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