| Identification | More | [Name]
2,3-Dichloropyridine | [CAS]
2402-77-9 | [Synonyms]
2,3-DICHLOROPYRIDINE
2,3-dichloro-pyridin
2,3-Dichloropyridine147.99
2,3-Dichloropyridine,99%
2,3-DICHLOROPYRIDINE 2,3-DICHLOROPYRIDINE
2,3-dichloropydine
2,3-Dichloropyridine ,98% | [EINECS(EC#)]
219-281-8 | [Molecular Formula]
C5H3Cl2N | [MDL Number]
MFCD00006229 | [Molecular Weight]
147.99 | [MOL File]
2402-77-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White to slightly beige crystalline powder | [Melting point ]
64-67 °C (lit.) | [Boiling point ]
242.42°C (rough estimate) | [density ]
1.5159 (rough estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Crystalline Powder | [pka]
-0.63±0.10(Predicted) | [color ]
White to slightly beige | [Water Solubility ]
slightly soluble | [Detection Methods]
GC | [BRN ]
109811 | [InChI]
InChI=1S/C5H3Cl2N/c6-4-2-1-3-8-5(4)7/h1-3H | [InChIKey]
MAKFMOSBBNKPMS-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=CC=C1Cl | [CAS DataBase Reference]
2402-77-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN2811 | [WGK Germany ]
3
| [RTECS ]
US8050000
| [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [HS Code ]
29333999 |
| Hazard Information | Back Directory | [Chemical Properties]
White to slightly beige crystalline powder | [Uses]
2,3-Dichloropyridine is used as a reagent for the preparation of substituted 3-(5-membered heterocycle-carboxamido)pyridine derivatives for treatment of autoimmune and inflammatory diseases. Also in the synthesis, crystal structure and biological activity of novel anthranilic Diamide insecticide with propargyl ether.
| [Synthesis]
2,3-dichloropyridine is synthesized from 2-chloronicotinic acid via amidation, Hofmann degradation, diazotization and Sandmeyer reaction.
| [Structure and conformation]
The complete mol-ecule of 2,3-Dichloropyridine, C5H3Cl2N, is generated by crystallographic twofold symmetry, which forces the pyridine N atom and the opposite C—H group to be statistically disordered. In the crystal, weak aromatic π–π stacking [centroid–centroid separation = 3.805 (4)Å and slippage = 1.704Å] leads to [100] stacks of mol-ecules. Short Cl···Cl contacts [3.334 (3)Å] are also observed. Colourless prisms were grown from ethanol.
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