| Identification | More | [Name]
1-Aminocyclopropanecarboxylic acid | [CAS]
22059-21-8 | [Synonyms]
1,1-ACCP
1-AMINO-1-CYCLOPROPANECARBOXYLIC ACID
1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID
1-AMINOCYCLOPROPANECARBOXYLIC ACID
ACC
ACPC
CARBOXYCYCLOPROPYLAMINE
H-(1)NHCPROPN-OH
H-ACPC-OH
1-amino-cyclopropanecarboxylicaci
alpha-aminocyclopropanecarboxylicacid
1-AMINO-1-CYCLOPROPANECARBOXYLIC ACID, 9 7%
Cyclopropanecarboxylicacid,1-amino-(6CI,7CI,8CI,9CI)
H-ACC-OH.HCl
a-Aminocyclopropanecarboxylic acid
Ac3c | [EINECS(EC#)]
217-162-5 | [Molecular Formula]
C4H7NO2 | [MDL Number]
MFCD00009944 | [Molecular Weight]
101.1 | [MOL File]
22059-21-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline | [Melting point ]
229-231 °C (lit.) | [Boiling point ]
189.47°C (rough estimate) | [density ]
1.2245 (rough estimate) | [refractive index ]
1.4340 (estimate) | [storage temp. ]
Store at 0°C | [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
Powder and Granules | [pka]
2.29±0.20(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble in water. | [Usage]
An NMDA agonist acting at the glycine site. | [BRN ]
2076413 | [Stability:]
Store in freezer at -20°C | [InChI]
InChI=1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7) | [InChIKey]
PAJPWUMXBYXFCZ-UHFFFAOYSA-N | [SMILES]
C1(N)(C(O)=O)CC1 | [CAS DataBase Reference]
22059-21-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
GZ1110000
| [Hazard Note ]
Irritant | [HS Code ]
29213000 |
| Hazard Information | Back Directory | [Description]
1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence.1 ACPC has been shown to modulate NMDA receptor activity by acting as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.2 | [Chemical Properties]
Crystalline | [Uses]
1-Aminocyclopropane-1-carboxylic Acid is a plant growth regulator. It is an NMDA agonist acting at the glycine site. | [Definition]
ChEBI: A non-proteinogenic alpha-amino acid consisting of cyclopropane having amino and carboxy substituents both at the 1-position. | [Synthesis Reference(s)]
Synthetic Communications, 18, p. 141, 1988 DOI: 10.1080/00397918808077338
Synthesis, p. 127, 1984 | [General Description]
1-Aminocyclopropanecarboxylic acid is a member of 1-aminocycloalkanecarboxylic acids. | [Biochem/physiol Actions]
1-Aminocyclopropanecarboxylic acid (ACC) exhibits anticonvulsant, anxiolytic, anti-addictive, neuroprotective and antidepressant-like effects in rats and mice. ACC does not affect memory or learning processes. |
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