| Identification | More | [Name]
Sodium dichloroacetate | [CAS]
2156-56-1 | [Synonyms]
DICHLOROACETIC ACID SODIUM SALT
NATRIUMDICHLORACETAT
SDA
SODIUM DICHLOROACETATE
dichloroacetate,sodiumsalt
dichloro-aceticacisodiumsalt
dichloroctansodny
Sodiumdichloracetate
Sodiumdichloroacetate,97%
SODIUM DICHLOROACETIC ACID
dlchloroacetic acid sodium salt
Dichloroacetate Sodium
Sodium 2,2-dichloroacetate | [EINECS(EC#)]
218-461-3 | [Molecular Formula]
C2HCl2NaO2 | [MDL Number]
MFCD00070489 | [Molecular Weight]
150.92 | [MOL File]
2156-56-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
198 °C (dec.) (lit.) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Powder | [color ]
White | [PH]
6.0 to 8.5(50g/L, 25 ℃) | [Water Solubility ]
soluble in cold water | [Sensitive ]
Moisture Sensitive | [Stability:]
Hygroscopic | [InChIKey]
LUPNKHXLFSSUGS-UHFFFAOYSA-M | [CAS DataBase Reference]
2156-56-1(CAS DataBase Reference) | [EPA Substance Registry System]
2156-56-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
2811 | [WGK Germany ]
2
| [RTECS ]
AG9275000
| [HS Code ]
29154000 |
| Questions And Answer | Back Directory | [Uses]
Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and is an orally absorbable small molecular compound for MELAS syndrome, and children with congenital lactic acidosis and other diseases that are treated in the clinic. Recent studies had found that DCA acts as a potential vasoprotective agent by inhibiting PDK2 and reducing coronary endarterium proliferation. Further, DCA promotes brain regeneration after cerebral ischemia, which indicates that DCA might play an important role in VD.
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| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Brand name]
Ceresine (Cypros). | [General Description]
Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity. | [Biological Activity]
Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of K V 1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo . | [storage]
Desiccate at RT |
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