| Identification | More | [Name]
Diclofenac sodium | [CAS]
15307-79-6 | [Synonyms]
2-(2,6-DICHLOROANILINO)PHENYLACETIC ACID SODIUM SALT
2-[(2,6-DICHLOROPHENYL)AMINO]-BENZENEACETIC ACID MONOSODIUM SALT
2-[(2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, NA
2-[(2,6-DICHLOROPHENYL)AMINO]-BENZENEACETIC ACID SODIUM SALT
AKOS B020028
AURORA KA-854
BENFOFEN
DICHRONIC
DICLOFENAC SODIUM
DICLOFENAC SODIUM DMF
DICLOFENAC SODIUM SALT
ECOFENAC
KROPLEX
NERIODIN
SODIUM 2-(2,6-DICHLOROANILINO)PHENYLACETATE
VALETAN
VOLTAREN
VOLTAROL
(o-(2,6-dichloroanilino)phenyl)aceticacidmonosodiumsalt
(o-(2,6-dichloroanilino)phenyl)aceticacidsodiumsalt | [EINECS(EC#)]
239-346-4 | [Molecular Formula]
C14H10Cl2NNaO2 | [MDL Number]
MFCD00082251 | [Molecular Weight]
318.13 | [MOL File]
15307-79-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Crystalline Solid | [Melting point ]
288-290°C | [density ]
0.781 g/cm3 | [storage temp. ]
room temp | [solubility ]
H2O: 50 mg/mL
| [form ]
White solid | [pka]
4(at 25℃) | [color ]
White to Almost white | [Stability:]
Stable. | [Water Solubility ]
Soluble in water to 50mg/ml. | [Usage]
A nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor | [Merck ]
3081 | [BCS Class]
2 | [InChI]
InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1 | [InChIKey]
KPHWPUGNDIVLNH-UHFFFAOYSA-M | [SMILES]
C1(=CC=CC=C1CC([O-])=O)NC1=C(Cl)C=CC=C1Cl.[Na+] | [CAS DataBase Reference]
15307-79-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
AG6330000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29224900 | [Toxicity]
LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp) |
| Questions And Answer | Back Directory | [description]
Diclofenac Sodium (Diclofenac sodium) is the sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever.
| [Uses]
Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs (NSAIDs). It exhibits analgesic, antipyretic and anti-inflammatory activity. Due to its poor solubility, the parenteral formulation of diclofenac sodium (Voltarol ampoules) currently available in Europe contains the solvents propylene glycol and benzyl alcohol that allows intramuscular and intravenous administration. Diclofenac sodium has long been used to treat acute pain and inflammation, and is effective in various acute forms of pain.
| [Mechanisms of action]
Putative mechanisms of action of diclofenac may include inhibition of leukotriene synthesis, inhibition of phospholipase A2, modulation of free arachidonic acid levels, stimulation of adenosine triphosphate-sensitive potassium channels via the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway and centrally mediated and neuropathic mechanisms. Other emerging mechanisms of action may include inhibition of peroxisome proliferator activated receptor-c, reduction in plasma and synovial substance P and interleukin-6 levels, inhibition of the thromboxane-prostanoid receptor and inhibition of acid-sensing ion channels.
| [Clinical Application]
Clinical trials have demonstrated the analgesic efficacy of diclofenac sodium in terms of relieving moderate to severe postoperative pain in patients undergoing dental surgery or minor orthopaedic surgery. Subcutaneous diclofenac sodium also effectively relieved moderate to severe neuropathic pain, related to cancer or not. Diclofenac sodium was generally well tolerated in clinical trials, with injection-site reactions among the most commonly reported adverse events.
|
| Hazard Information | Back Directory | [Description]
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively).1,2 It is also an active metabolite of diclofenac methyl ester (Item No. 22218) and diclofenac amide (Item No. 21969).3,4 Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 (Item No. 11016) in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 μM, respectively).5 Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats.6 Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. | [Chemical Properties]
Off-White Crystalline Solid | [Originator]
Voltaren,Fujisawa,Japan,1974 | [Definition]
ChEBI: The sodium salt of diclofenac. | [Manufacturing Process]
Four grams of N-chloroacetyl-N-phenyl-2,6-dichloroaniline and 4 grams of
aluminum chloride are well mixed together and heated for 2 hours at 160°C.
The melt is cooled and poured onto about 50 grams of ice while it is still
warm. The oil which separates is dissolved in 50 ml of chloroform, the
chloroform solution is washed with 10 ml of water, dried over sodium sulfate
and concentrated under 11 torr. The residue is distilled. The 1-(2,6-
dichlorophenyl)-2-indolinone melts at 126°-127°C.
A solution of 186 grams of 1-(2,6-dichlorophenyl)-2-indolinone in 660 ml of
ethanol and 660 ml of 2 N sodium hydroxide solution is refluxed for 4 hours.
The solution is then cooled and left to stand for 4 hours at 0°-5°C. The
crystals which form are filtered off and recrystallized from water. The sodium
salt of 2-(2,6-dichloroanilino)-phenylacetic acid melts at 283°-285°C. The
yield is 97% of theoretical, according to US Patent 3,558,690. | [Brand name]
Solaraze (Bioglan); Voltaren (Novartis);Aflamin;Alfamin;Allvoran;Artren;Blesin;B-voltaren;Cgp 9194;Chlorgyl;Ct-diclo;Dichloronic;Diclo attritin;Diclo spondril;Diclo-attritin;Diclo-burg;Diclo-phlohont;Diclo-puren;Diclo-recip;Dicloreum;Diclo-spondyril;Diclo-wolf;Dolobasan;Dolotrem;Doragon;Duravolten;Duvavotten;Feloran;Fenoflam;Flogofenac;Flogogenac;Forgenac;Inflamac;Klast;Monoflam;Myogit;Neuro-effekton;Neurofenac;Neuro-voltaren;Neviodin;Olfen;Panamor;Rewodina;Rheumalgen;Rheumavincin-n;Seecoren;Shignol;Silino;Sofarin;Thicataren;Toryxil;Tsudomin;Voltarene. | [Therapeutic Function]
Antiinflammatory | [World Health Organization (WHO)]
The World Health Organization currently has no information to
suggest that diclofenac is less safe than other widely available non-steroidal
antiinflammatory substances of this type, or that children are particularly liable to
react adversely. It is registered in many countries in several dosage forms,
including a 12.5 mg suppository indicated for juvenile arthritis. | [General Description]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diclofenac is a derivative of benzeneacetic acid. It is categorized under the class of non-steroidal anti-inflammatory drugs (NSAIDs). It shows inflammatory, analgesic and antipyretic activities. | [Biochem/physiol Actions]
Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4′-hydroxydiclofenac and 5′-hydroxydiclofenac. Has been used as substrate selective for CYP2C9. | [Clinical Use]
Diclofenac sodium is indicated for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. | [Veterinary Drugs and Treatments]
The equine topical cream (Surpass?) is labeled for the control of
pain and inflammation associated with osteoarthritis in tarsal, carpal,
metacarpophalangeal, metarsophalangeal, and proximal interphalangeal
(hock, knee, fetlock, pastern) joints for use up to 10 days
duration. While, theoretically, diclofenac could be used systemically
(orally) in other veterinary species, there are approved and safer
alternatives. | [Drug interactions]
Potentially hazardous interactions with other drugs
antagonism of hypotensive effect; increased risk of
nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more
NSAIDs, including aspirin (increased side effects);
avoid with ketorolac (increased risk of side effects
and haemorrhage).
Antibacterials: possibly increased risk of convulsions
with quinolones; concentration reduced by
rifampicin.
Anticoagulants: effects of coumarins and
phenindione enhanced; possibly increased risk of
bleeding with heparins, dabigatran and edoxaban -
avoid long term use with edoxaban; increased risk of
haemorrhage with IV diclofenac - avoid.
Antidepressants: increased risk of bleeding with
SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas
enhanced.
Antiepileptics: possibly increased phenytoin
concentration.
Ciclosporin: may potentiate nephrotoxicity;
concentration increased by ciclosporin.
Cytotoxics: reduced excretion of methotrexate;
increased risk of bleeding with erlotinib. | [Metabolism]
Diclofenac undergoes first-pass metabolism and is It is then excreted in the form of glucuronide and sulfate
conjugates, mainly in the urine (about 60%) but also in
the bile (about 35%).
then extensively metabolised to 4′-hydroxydiclofenac,
5-hydroxydiclofenac, 3′-hydroxydiclofenac, and
4′,5-dihydroxydiclofenac by glucuronidation of the intact
molecule or more commonly by single and multiple
hydroxylation followed by glucuronidation. | [storage]
Store at RT |
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