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ChemicalBook--->CAS DataBase List--->1433997-01-3

1433997-01-3

1433997-01-3 Structure

1433997-01-3 Structure
IdentificationBack Directory
[Name]

Mal-PEG2-NHS ester
[CAS]

1433997-01-3
[Synonyms]

Mal-PEG2-NHS ester
2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethoxy)ethoxy)propanoate
Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
[Molecular Formula]

C15H18N2O8
[MDL Number]

MFCD24539465
[MOL File]

1433997-01-3.mol
[Molecular Weight]

354.31
Chemical PropertiesBack Directory
[Boiling point ]

524.3±60.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[solubility ]

Soluble in DCM
[pka]

-2.34±0.20(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H335-H319-H315
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard InformationBack Directory
[Description]

Mal-PEG2-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
[Uses]

Mal-?PEG2-?NHS Ester is a reagent used in the preparation of antibody-drug conjugates that bind to human-antigen targets in the effort to combat cancers.
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