| Identification | Back Directory | [Name]
Glycyrrhizic acid | [CAS]
1405-86-3 | [Synonyms]
glycyron
liquorice
Potenlini
DerMacrin
NSC 167409
NSC 234419
Glycyrrhizic
GLYCYRRHIZIN
Glycyrrhitin
Glycyrrhizine
GLYCYRRHIZINATE
Of glycyrrhizin
GLYCYRRHYCIC ACID
GLYCYRRHIZIC ACID
beta-glycyrrhizin
Glycyrrhizin std.
glycyrrhizinicacid
Radix Glycyrrhizae
glycyrrhizic acid A
glucopyranuronosyl-
GLYCYRRHIZIC ACID(P)
18β-Glycyrrhizic acid
Glycyrrhizic acid (8CI)
Potassium Glycyrrhetate
18-beta-glycyrrhizicacid
Glycyrrhizic Acid (25 mg)
GLYCYRRHIZIC ACID(P)(CALL)
GLYCYRRHETINIC ACID GLYCOSIDE
Glycyrrhizin (Glycyrrhizic Acid)
Glycyrrhisinic acid power 21% W/W
-alpha-d-glucopyranosiduronicacid
Glycyrrhizinate acid 15-18% (R-19)
Glycyrrhizinic acid (Glycyrrhizin)
-12-en-3-yl-2-o-beta-d-glucopyranuronosyl-
β-D-Glucopyranosiduronic acid, (3β,20β)-20-
ean-12-en-3-yl2-o-beta-d-glucopyranuronosyl-
carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-
30-Noroleanane, a-D-glucopyranosiduronic acid deriv.
glucopyranuronosyl-.alpha.-D-Glucopyranosiduronic acid
alpha-d-glucopyranosiduronicacid,(3beta,20beta)-20-carboxy-11-oxo-30-norol
alpha-d-glucopyranosiduronicacid,(3beta,20beta)-20-carboxy-11-oxo-30-norolean
20beta-carboxy-11-oxo-30-norolean-12-en-3beta-yl-2-o-beta-d-glucopyranuronosyl
3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid
3-o-(2-o-beta-d-glucopyranuronosyl-alpha-d-glucopyranuronosyl)-18beta-g lycyrrhetinic acid
(20S)-3β-[(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)oxy]-11-oxoolean-12-en-30-oic acid
(3β,20β)-20-Carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-Glucopyranuronosyl-α-
D-glucopyranosiduronic Acid
a-D-Glucopyranosiduronic acid, (3b,20b)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-b-D-glucopyranuronosyl-
α-D-Glucopyranosiduronic acid, (3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-
Glycyrrhizic acid
3-O-(2-O-beta-D-Glucopyranuronosyl-alpha-D-glucopyranuronosyl)-18beta-g lycyrrhetinic acid
(3beta,20beta)-20-Carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-1-7-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid
(3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl2-O-.beta.-D-glucopyranuronosyl-.alpha.-D-Glucopyranosiduronicacid
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-
5-[(6-carboxy-3,4,5-trihydroxyoxan-2-yl)oxy]-6-[(11-carboxy-4,4,6a,6b,8a,11,14b-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy]-3,4-dihydroxyoxane-2-carboxylic acid | [EINECS(EC#)]
215-785-7 | [Molecular Formula]
C42H62O16 | [MDL Number]
MFCD00065194 | [MOL File]
1405-86-3.mol | [Molecular Weight]
822.93 |
| Chemical Properties | Back Directory | [Melting point ]
220°C (rough estimate) | [alpha ]
D17 +46.2° (c = 1.5 in alc) | [Boiling point ]
681.01°C (rough estimate) | [density ]
1.1442 (rough estimate) | [refractive index ]
61 ° (C=1.5, EtOH) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO (Slightly), Ethanol (Slightly), Methanol (Sparingly), Pyridine (Slightly) | [form ]
Solid | [pka]
2.76±0.70(Predicted) | [color ]
White to Light Yellow | [Odor]
at 100.00 %. mild spicy | [Odor Type]
spicy | [Merck ]
4505 | [Stability:]
Hygroscopic | [InChIKey]
BXFBITNYMHAJGT-KYXJNIQISA-N | [LogP]
4.64 | [Uses]
Glycyrrhizin is a flavorant and foaming agent derived from the separation of flavonoids found in the whole licorice extract from the licorice root glycyrrhiza glabra. It is 50–100 times as sweet as sugar, is soluble in water, and has a licorice taste. It has good heat stability but prolonged heating can result in some degradation. It is stable within ph 4–9; below ph 4 there could be precipitation. It has foaming and emulsifying properties in water, being used in cocktail mixes and soft drinks. It is used as a flavorant in bacon and imitation whipped products. It is synergistic with sugar, the sweetness being amplified to 100 times that of cane sugar alone. It is used as a sweetener in sugar-free chewing gum and low-fat sugar-free frozen desserts. It is also termed ammoniated glycyrrhizin. Monoammonium glycyrrhizinate is obtained by additional refinement. | [CAS DataBase Reference]
1405-86-3 | [EPA Substance Registry System]
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-(1405-86-3) |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Usage]
11beta-hydroxysteroid dehydrogenase inhibitor, antiinflammatory, expectorant, antihaemorrhagic, anti-HIV | [Usage]
Glycyrrhizic acid is a triterpene saponin used in the traditional Chinese medicinal preparation for its anti-inflammatory , antiulcerous and antiallergic effects. | [Definition]
ChEBI: A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid. | [storage]
Store at 2-8℃ |
| Safety Data | Back Directory | [Safety Statements ]
22-24/25 | [WGK Germany ]
3 | [RTECS ]
MD2025000 | [HS Code ]
29389000 | [Safety Profile]
Poison by intravenous
route. Moderately toxic by ingestion and
intraperitoneal routes. Human systemic
effects by ingestion: somnolence and
changes in the metabolism of phosphorus,
When heated to decomposition it emits
acrid smoke and irritating fumes. | [Hazardous Substances Data]
1405-86-3(Hazardous Substances Data) | [Toxicity]
human,TDLo,oral,5571ug/kg/3D- (5.571mg/kg),KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION,Toxicologist. Vol. 54, Pg. 109, 2000. |
| Questions And Answer | Back Directory | [Description]
Glycyrrhizic acid is a kind of anti-inflammatory triterpene glycoside extracted from the licorice root. Inside the body, it can be metabolized to glycyrrhetinic acid which inhibits the 11-beta-hydroxysteroid dehydrogenase and some other enzymes related to the corticosteroid metabolism. Glycyrrhizic acid has various pharmacological effects including suppressing hepatic apoptosis and necrosis, anti-inflammatory and immune regulatory actions, antiviral effects, antineoplastic and anticancer effects. It is the active ingredient of licorice root which is commonly used in the treatment of acute and chronic liver injury, viral hepatitis, hepatic steatosis, liver fibrosis, hepatoma, viral myocarditis and other diseases such as psoriasis or prostate cancer. Glycyrrhizic acid is also widely used as a sweetening and flavoring agent in food.
| [References]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052927/
https://pubchem.ncbi.nlm.nih.gov/compound/Glycyrrhizic_acid#section=Top
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