| Identification | More | [Name]
3'-Hydroxypropiophenone | [CAS]
13103-80-5 | [Synonyms]
3-HYDROXY PROPIOPHENONE
3'-HYDROXYPROPIOPHENONE
1-(3-hydroxyphenyl)propan-1-one | [EINECS(EC#)]
236-027-1 | [Molecular Formula]
C9H10O2 | [MDL Number]
MFCD03428514 | [Molecular Weight]
150.17 | [MOL File]
13103-80-5.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . |
| Hazard Information | Back Directory | [Uses]
1-?(3-?Hydroxyphenyl)?-?1-?propanone is a reactant used to synthesize tricyclic fused pyridines, a family of alkaloids with antimalarial activity. | [Preparation]
Preparation by diazotization of m-aminopropiophenone, followed by decomposition of the diazonium salt obtained, (71%)
Also obtained by saponification of 3-acetoxypropiophenone (b.p.2 127–128°) with refluxing 10% sodium hydroxide for 2–3 h (83%)
Also obtained by reductive deamination of 2-amino-5-hydroxypropiophenone (diazotization, followed by decomposition of the diazonium salt formed with copper powder in ethanol)
Also obtained by reaction of ethylmagnesium bromide with 3-hydroxy-N, N-diethylbenzamide in refluxing n-butyl ether for 4 h (75%)
Also obtained by treatment of 3-methoxypropiophenone (b.p.0.05 70–76°) with pyridinium chloride at 210° for 30 min (85%)
Also obtained by treatment of 1-hydroxy-1-(3-hydroxyphenyl)propane (m.p. 105–107°) with DDQ in dioxane for 72 h (97%). |
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