| Identification | More | [Name]
Prednisone 21-acetate | [CAS]
125-10-0 | [Synonyms]
1,4-PREGNADIEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE
1,4-PREGNADIEN-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE
17 ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE-21-ACETATE
1-DEHYDROCORTISONE ACETATE
[2-[(8s,9s,10s,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
ACETIC ACID 2-((8S,9S,10R,13S,14S,17R)-17-HYDROXY-10,13-DIMETHYL-3,11-DIOXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-17-YL)-2-OXO-ETHYL ESTER
prednisone 21-acetate
PREDNISONE ACETATE
11,20-trione,21-(acetyloxy)-17-hydroxy-pregna-4-diene-3
4-diene-3,11,20-trione,17,21-dihydroxy-pregna-21-acetate
delcortin
delta’-dehydrocortisoneacetate
delta-corlin
deltalone
nisone
Dehydrocortisone acetate
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione-21-acetate
17α,21-Dihydroxypregna-1,4-diene-3,11,20-trioneacetate
[2-[(8S,9S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate | [EINECS(EC#)]
204-726-0 | [Molecular Formula]
C23H28O6 | [MDL Number]
MFCD00200229 | [Molecular Weight]
400.46 | [MOL File]
125-10-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
240-242°C (dec.) | [alpha ]
D25 +186° (dioxane) | [Boiling point ]
582.0±50.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.31±0.60(Predicted) | [color ]
White to Off-White | [Water Solubility ]
23mg/L(25 ºC) | [CAS DataBase Reference]
125-10-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Adrenocortical steroid antiinflammatory. | [Definition]
ChEBI: Cortancyl is a steroid ester, a 20-oxo steroid, an acetate ester, a 17alpha-hydroxy steroid, an 11-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a prednisone. | [in vivo]
Prednisone acetate (5 mg/kg, Intragastric gavage, once a day for 4 weeks) induces hippocampal LTP impairment by causing neuronal lesions in the dentate gyrus, which reduced glutamic acid (Glu) and NMDAR2A, and impaired spatial memory in Hippocampal LTP impairment model mice[1].
Prednisone acetate (6 mg/kg, gavage, once a day for 15 days) reduces ocular and peripheral inflammatory responses and restores Th1/Th2 and Th17/Treg immune homeostasis through orchestrating the Notch signaling pathway in Experimental autoimmune uveitis (EAU) rats[2]. | Animal Model: | C57BL/6 mice [1] | | Dosage: | 5 mg/kg | | Administration: | Intragastric gavage (i.g.) | | Result: | Significantly failed to gain weight.
Decreased the population spike (%) after high-frequency stimulation.
Reduced the crossing times compared with the control group.
Resulted in the impairment of memory, and caused a trend of more serious impairment.
Reduced the levels of Glu and gamma-aminobutyric acid (GABA) in the hippocampus.
Reduced the expressions of N-methyl-D-aspartate receptors in the hippocampus. |
| Animal Model: | Experimental autoimmune uveitis [2] | | Dosage: | 6 mg/kg | | Administration: | gavage | | Result: | Showed fewer manifestations in eyes from day 9 after immunization.
Reduced the inflammation in EAU rats.
Bound with the pocket of Notch signaling-related molecules with good affinity.
Exhibited anti-inflammatory effects through inhibiting Notch signaling activation.
Decreased Th1, Th17 and increased Th2, Treg frequencies in EAU. |
| [IC 50]
IL-17; IL-10; IL-4 |
|
|