| Identification | More | [Name]
Dodecyl alcohol | [CAS]
112-53-8 | [Synonyms]
1-DODECANOL
1-DODECYLALCOHOL
ALCOHOL C12
ALCOHOL C-12 LAURIC
DODECAN-1-OL
DODECANOL
DODECYL ALCOHOL
FEMA 2617
LAURYL ALCOHOL
N-DODECYL ALCOHOL
RARECHEM AL BD 0157
TIMTEC-BB SBB008734
1-Hydroxydodecane
Alfol 12
alfol12
Cachalot l-50
Cachalot l-90
cachalotl-50
cachalotl-90
CO 12 | [EINECS(EC#)]
203-982-0 | [Molecular Formula]
C12H26O | [MDL Number]
MFCD00004753 | [Molecular Weight]
186.33 | [MOL File]
112-53-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white low melting crystalline solid | [Melting point ]
22-26 °C(lit.)
| [Boiling point ]
260-262 °C(lit.)
| [density ]
0.833 g/mL at 25 °C(lit.)
| [vapor density ]
7.4 (vs air)
| [vapor pressure ]
0.1 mm Hg ( 20 °C)
| [FEMA ]
2617 | [refractive index ]
n20/D 1.442(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
water: slightly soluble1g/L at 23°C | [form ]
Liquid | [pka]
15.20±0.10(Predicted) | [color ]
APHA: ≤10 | [Odor]
Typical fatty alcohol odor; sweet. | [explosive limit]
4% | [Odor Type]
waxy | [Water Solubility ]
insoluble | [JECFA Number]
109 | [Merck ]
14,3405 | [BRN ]
1738860 | [Dielectric constant]
6.5（24℃） | [InChIKey]
LQZZUXJYWNFBMV-UHFFFAOYSA-N | [LogP]
5.4 at 23℃ | [Uses]
lauryl alcohol is used in chemical formulations for a variety of purposes, including as an emulsion stabilizer, a skin-conditioning emollient, and a viscosity-increasing agent. | [CAS DataBase Reference]
112-53-8(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Dodecanol(112-53-8) | [EPA Substance Registry System]
112-53-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
R38:Irritating to the skin.
R50:Very Toxic to aquatic organisms.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/38:Irritating to eyes and skin .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S37/39:Wear suitable gloves and eye/face protection .
S29:Do not empty into drains .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S60:This material and/or its container must be disposed of as hazardous waste .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
1
| [RTECS ]
JR5775000
| [Autoignition Temperature]
500 °F | [TSCA ]
Yes | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29051700 | [Safety Profile]
Moderately toxic by
intraperitoneal route. Mildly toxic by ingestion. A
severe human skin irritant. Questionable
carcinogen with experimental tumorigenic data.
Combustible when exposed to heat or flame; can
react with oxidizing materials. To fight fire, use dry
chemical, CO2. When heated to decomposition it
emits acrid smoke and irritating fumes | [Hazardous Substances Data]
112-53-8(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: > 5000 mg/kg |
| Hazard Information | Back Directory | [General Description]
Colorless thick liquid with a sweet odor. Floats on water. Freezing point is 75°F. | [Reactivity Profile]
DODECANOL is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. | [Health Hazard]
Liquid will cause burning of the eyes and may irritate skin. | [Description]
Lauryl alcohol has a characteristic fatty odor. It is unpleasant at
high concentrations but delicate and floral on dilution. It has a
fatty, waxy flavor. It may be prepared by hydrogenation of lauric
acid; normally employed as a replacement for the corresponding
aldehyde. | [Chemical Properties]
1-Dodecanol is a crystalline solid that has a melting point of
24°C.The air odor threshold for dodecyl alcohol (isomer not
specified) is reported to be 7.1 ppb. | [Chemical Properties]
Lauryl alcohol has a characteristic fatty odor; unpleasant at high concentrations, but delicate and floral on dilution. It
has a fatty, waxy flavor. | [Chemical Properties]
white low melting crystalline solid | [Physical properties]
1-Dodecanol is a white low melting crystalline solid that has a melting point of 24°C.The air odor threshold for dodecyl alcohol (isomer not specified) is reported to be 7.1 ppb. | [Occurrence]
Reported found in the oil of Mexican lime and in the oil from flowers of Furcraea gigantean. Also reported
found in apple, banana, sour cherry, citrus peel oils, melon, pineapple, potato, thymus, cheeses, butter, milk powder, chicken and beef
fat, cooked pork, beer, whiskies, white wine, peanuts, beans, mushrooms, mango, coriander seed and leaf, rice, Bourbon vanilla,
endive, crab, clam, Cape gooseberry, pawpaw and maté.
| [Definition]
ChEBI: A fatty alcohol that is dodecane in which a hydrogen from one of the methyl groups is replaced by a hydroxy group. It is registered for use in apple and pear orchards as a Lepidopteran pheromone/sex attractant, used to disrupt the mating behaviour of certa
n moths whose larvae destroy crops. | [Preparation]
Commercially prepared by hydrogenation of lauric acid; normally employed as a replacement for the corresponding
aldehyde.
| [Production Methods]
1-Dodecanol is produced commercially by the oxo process
and from ethylene by the Ziegler process, which involves
oxidation of trialkylaluminum compounds. It can also be
produced by sodium reduction or high-pressure hydrogenation
of esters of naturally occurring lauric acid. | [Aroma threshold values]
Detection: 73 to 820 ppb | [Synthesis Reference(s)]
Journal of the American Chemical Society, 108, p. 6036, 1986 DOI: 10.1021/ja00279a061
Tetrahedron Letters, 37, p. 3623, 1996 DOI: 10.1016/0040-4039(96)00652-1 | [Flammability and Explosibility]
Nonflammable | [Chemical Reactivity]
Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent. | [Carcinogenicity]
1-Dodecanol showed weak tumor-promoting activity when applied three times a week
for 60 weeks to the skin of mice that had previously received
an initiating dose of dimethylbenz[a]anthracene. Papillomas
developed in 2 of 30 mice after 39 and 49 weeks of treatment. | [Metabolism]
See alcohol C-8. | [storage]
Store at -20°C | [Purification Methods]
Crystallise dodecanol from aqueous EtOH, and distil it through a spinning-band column under vacuum. [Ford & Marvel Org Synth 10 62 1930, Beilstein 1 IV 1844.] |
|
|