| Identification | More | [Name]
Risedronic acid | [CAS]
105462-24-6 | [Synonyms]
(1-HYDROXY-1-PHOSPHONO-2-PYRIDIN-3-YL-ETHYL)PHOSPHONIC ACID
RESEDRONIC ACID
RISEDRONATE
RISEDRONIC ACID
RISEDRONIC ACID MONOHYDRATE
1-Hydroxy-2-(3-pyridyl)-ethan-1,1-bis-phosphonic acid
RISEDRONIC ACID: RISEDRONIC ACID MONOHYDRATE
1-Hydroxy-2-(3-pyridinyl)ethylidenebisphosphonicacidmonohydrate
1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE]BISPHOSPHONIC ACID
3-(Acetic acid)Pyridine | [EINECS(EC#)]
600-654-2 | [Molecular Formula]
C7H11NO7P2 | [MDL Number]
MFCD00867080 | [Molecular Weight]
283.11 | [MOL File]
105462-24-6.mol |
| Hazard Information | Back Directory | [Uses]
Risedronic acid is a potentially useful biophosphonate for bone resorption analysis.
| [Uses]
Risedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor. | [Definition]
ChEBI: Risedronic acid is a member of pyridines. It is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease. It functions by preventing resorption of bone. | [storage]
Store at -20°C | [Mode of action]
Risedronatic acid binds to bone hydroxyapatite. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis. Endocytic vesicles are acidified, releasing risedronic acid to the cytosol of osteoclasts where they induce apoptosis through inhbition of farnesyl pyrophosphate synthase. Inhibition of osteoclasts results in decreased bone resorption. |
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