| Identification | More | [Name]
2-Hydroxy-5-methylpyridine | [CAS]
1003-68-5 | [Synonyms]
2-HYDROXY-5-METHYLPYRIDINE
2-HYDROXY-5-PICOLINE
5-METHYL-2(1H)PYPRIDINONE
5-METHYL-2(1H)-PYRIDINONE
5-METHYL-2(1H)PYRIDONE
5-METHYL-2-PYRIDINOL
5-METHYL-PYRIDIN-2-OL
5-METHYLPYRIDINE-2-ONE
6-HYDROXY-3-PICOLINE
AKOS BBS-00002970
2(1H)-Pyridinone, 5-methyl-
2(1H)-Pyridone, 5-methyl-
2-Methyl-6-hydroxypyridine
5-methyl-2-pyridone
2-Hydroxy-5-Picoline 2-Hydroxy-5-Methyl Pyridine
2-HYDROXY-5-METHYLPYRIDINE 98%
2-Hydroxy-5-Piocoline
5-Methyl-1,2-dihydropyridine-2-one
5-Methylpyridin-2(1H)-one
5-Methylpyridine-2-ol | [EINECS(EC#)]
213-713-9 | [Molecular Formula]
C6H7NO | [MDL Number]
MFCD03092888 | [Molecular Weight]
109.13 | [MOL File]
1003-68-5.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
183-187 °C (lit.) | [Boiling point ]
304.2±15.0 °C(Predicted) | [density ]
1.053±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.43±0.10(Predicted) | [color ]
Pale Yellow to Light Yellow | [BRN ]
107074 | [InChI]
InChI=1S/C6H7NO/c1-5-2-3-6(8)7-4-5/h2-4H,1H3,(H,7,8) | [InChIKey]
SOHMZGMHXUQHGE-UHFFFAOYSA-N | [SMILES]
C1(=O)NC=C(C)C=C1 | [CAS DataBase Reference]
1003-68-5(CAS DataBase Reference) | [NIST Chemistry Reference]
2(1H)-pyridinone, 5-methyl-(1003-68-5) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides. | [Definition]
ChEBI: 5-Methyl-2-pyridinol is a member of methylpyridines. | [Synthesis]
3-cyano-6-hydroxypyridine and sodium lauryl sulfate were added to a mixed solvent of n-butanol and water. Subsequently, the temperature was raised to 50 °C., and sulfuric acid water obtained by dissolving 98% sulfuric acid in water was added dropwise at the temperature. After stirring for about 20 minutes, the mixture was cooled to room temperature, and 5% Pd / C was added. The system was replaced with hydrogen, and hydrogenation was carried out at atmospheric pressure for 6 hours. After the reaction was completed, the catalyst was removed by filtration, and the solution was washed with 10% sodium hydroxide aqueous solution. After partially neutralizing to H = 5 and extraction with n-butanol, a solution of crude 3-methyl-6-hydroxypyridine in butanol was obtained. When this solution was quantified by liquid chromatography, the pass-through rate was 99.2%, and the yield of 2-hydroxy-5-methylpyridine was 83%.
| [References]
[1] Suresh Babu Bodempudi, ;K. S. Reddy, Ravichandra Babur. “Development and Substantiation of a RP-HPLC Method for Monitoring of Impurities in Pirfenidone Drug Substance.” 美國分析化學(英文) 6 1 (2015): 1019–1029.
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