| Identification | More | [Name]
2-Hydroxypyridine | [CAS]
142-08-5 | [Synonyms]
1,2-dihydro-2-oxopyridine
1H-2-Pyridone
1h-pyridin-2-one
2(1H)-PYRIDONE
2-HYDROXYPYRIDINE
2-oxopyridine
2-PYRIDINOL
2-pyridinone
2-PYRIDOL
2-PYRIDON
2-PYRIDONE
a-Hydroxypyridine
A-PYRIDONE
AURORA KA-3075
PYRIDIN-2-OL
TIMTEC-BB SBB004392
1-Hydroxy-2-pyridine
2(1h)-pyridinone
alpha-Pyridone
Pyridone-2 | [EINECS(EC#)]
205-520-3 | [Molecular Formula]
C5H5NO | [MDL Number]
MFCD00006268 | [Molecular Weight]
95.1 | [MOL File]
142-08-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal | [Melting point ]
105-107 °C (lit.) | [Boiling point ]
280-281 °C (lit.) | [density ]
1.39 | [refractive index ]
1.5939 (estimate) | [Fp ]
210 °C
| [storage temp. ]
Store at RT. | [solubility ]
450g/l | [form ]
Liquid | [pka]
0.75(at 20℃) | [color ]
Colorless to yellow to brown, darken on storage with no loss of purity | [Water Solubility ]
Soluble in water 450 g/L @ 20°C and ethanol, slightly soluble in benzene and ether. | [Detection Methods]
HPLC,NMR | [BRN ]
105786 | [LogP]
-0.593 (est) | [CAS DataBase Reference]
142-08-5(CAS DataBase Reference) | [NIST Chemistry Reference]
2(1H)-Pyridinone(142-08-5) | [Storage Precautions]
Light sensitive | [EPA Substance Registry System]
142-08-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S22:Do not breathe dust . | [RIDADR ]
UN2811 | [WGK Germany ]
3
| [RTECS ]
UV1144050
| [F ]
8 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29333990 | [Toxicity]
LD50 ipr-mus: 410 mg/kg TOXIA6 23,815,85 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
1,3-Dicyclohexylthiourea-->Allyl isothiocyanate-->Dicyclohexylcarbodiimide-->Carbonic acid, 1,1-dimethylethyl 2-pyridinyl ester (9CI)-->2(1H)-Pyridinone, 1-[[(4-methoxy-1-naphthalenyl)carbonyl]oxy]- (9CI)-->BOC-L-Tyrosine | [Preparation Products]
2-Hydroxy-5-bromopyridine-->DI-2-PYRIDYL THIONOCARBONATE-->Reactive Brilliant Yellow M-7G-->5-CHLOROPYRIDIN-2(1H)-ONE-->3,5-DICHLORO-2-PYRIDONE-->disodium 4-[[5-(aminocarbonyl)-1-ethyl-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-3-pyridyl]azo]-6-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzene-1,3-disulphonate-->2,3-Dihydroxypyridine-->(2-OXOPYRIDIN-1(2H)-YL)ACETIC ACID-->2-HYDRAZINO-3-NITROPYRIDINE |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal | [Uses]
Catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols1 and in the aminolysis of a polyglutamate.2 | [Definition]
ChEBI: A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2. | [General Description]
2-Hydroxypyridine, an enolic tautomer of 2-pyridone, belongs to the class of volatile organic compounds (VOCs). | [Safety Profile]
Moderately toxic by intraperitoneal and intravenous routes. A combustible liquid. When heated to decomposition it emits toxic vapors of NOx. | [Purification Methods]
Distil the pyridone under vacuum to remove coloured impurity, then recrystallise from *benzene, CCl4, EtOH or CHCl3/diethyl ether. It can be sublimed under high vacuum. [DePue et al. J Am Chem Soc 107 2131 1985, Beilstein 21/7 V 106.] |
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