Sacubitril Impurity 72 synthesis

3synthesis methods

Product Name:Sacubitril Impurity 72
CAS Number:1361408-16-3
Molecular formula:C23H27NO4
Molecular Weight:381.46

1-Pyrrolidinecarboxylic acid, 5-([1,1'-biphenyl]-4-ylmethyl)-3-methyl-2-oxo-, 1,1-dimethylethyl ester, (3R,5S)-

1038924-76-3
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1361408-16-3
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium hydride; potassium hexamethylsilazane / toluene / 1 h / -15 °C
1.2: 0.5 h / -15 °C
1.3: 1 h / 20 °C
2.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C

References:

NOVARTIS AG;HOOK, David;RISS, Bernhard;ZHOU, Jianguang;LI, Yunzhong;BAPPERT, Erhard WO2012/25502, 2012, A1

1H-Pyrrole-1-carboxylic acid, 5-([1,1'-biphenyl]-4-ylmethyl)-2,5-dihydro-3-methyl-2-oxo-, 1,1-dimethylethyl ester, (5R)-

1361408-15-2
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1361408-16-3
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References

1-Pyrrolidinecarboxylic acid, 5-([1,1'-biphenyl]-4-ylmethyl)-3-methylene-2-oxo-, 1,1-dimethylethyl ester, (5R)-

1174130-72-3
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1361408-16-3
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References

Sacubitril Impurity 72 Related Search:

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Sacubitril Impurity 72 synthesis

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