(S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one synthesis
- Product Name:(S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one
- CAS Number:195137-95-2
- Molecular formula:C17H15NO2
- Molecular Weight:265.31
Yield:195137-95-2 94%
Reaction Conditions:
with aluminum (III) chloride in dichloromethane at -5 - 20; for 3 h;Reagent/catalyst;Solvent;
Steps:
2
Under conditions -5 ~ 0 , the aluminum (23.3g, 174.8mmol) chloride solution in dichloromethane (180ml) was added dropwise compound (6.74g, 43.7mmol) in dichloromethane (80ml), was added dropwise complete.At room temperature, the reaction solution was added dropwise to the compound obtained in Example 1 embodiment, dropwise addition at room temperature stirred for 3h.Point TLC plate, raw material complete reaction.Water (500ml) was added to the system, liquid separation, the organic phase was dried and concentrated. to give crude compound.The crude product was THF / heptane: Recrystallization (1 2,70ml), off-white solid 10.91g, 94% yield.
References:
CN104829514,2017,B Location in patent:Paragraph 0028-0030; 0033-0035; 0038-0040; 0043-0045
![(S)-4-[(5-oxo-2-pyrrolidinyl)carbonyl]morpholine](/CAS/GIF/85187-29-7.gif)
85187-29-7
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195137-95-2
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